3-甲基吡唑-5-甲酸乙酯合成路线 （共 40 条）
反应条件
1: potassium tert-butylate 2: lithium aluminium tetrahydride View Scheme
参考文献
Harit, Tariq; Malek, Fouad; Bali, Brahim El; Khan, Ajmal; Dalvandi, Kourosh; Marasini, Bishnu P.; Noreen, Shagufta; Malik, Rizwana; Choudhary, M. Iqbal; Khan, Sadia
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 2772 - 2778,7
反应条件
1.1: 60 percent / t-BuOK / tetrahydrofuran / 15 h / Heating
2.1: LiAlH4 / tetrahydrofuran / 3 h / Heating
2.2: 85 percent / H2O, NaOH / 0.5 h
3.1: 70 percent / SOCl2 / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Malek, Fouad; Persin, Michel; Ramdani, Abdelkrim; Sarrazin, Jean; Zidane, Ismail
New Journal of Chemistry, 2002 , vol. 26, # 7 p. 876 - 882
反应条件
1.1: water; sodium hydroxide / methanol / 4 h / Reflux
1.2: pH 2 / Acidic conditions
2.1: sulfuric acid, fuming; nitric acid / 19 h / -5 - 60 °C
3.1: thionyl chloride / 4 h / Reflux
4.1: diethyl ether; water / 8 h / 0 - 20 °C
View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
反应条件
1.1: water; sodium hydroxide / methanol / 4 h / Reflux
1.2: pH 2 / Acidic conditions
2.1: sulfuric acid, fuming; nitric acid / 19 h / -5 - 60 °C
3.1: thionyl chloride / 4 h / Reflux
4.1: diethyl ether; water / 8 h / 0 - 20 °C
5.1: 0.5 Pd/C; hydrogen / methanol / 24 h / 20 °C / 6080.41 Torr
View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
反应条件
1: potassium tert-butylate
2: lithium aluminium tetrahydride
3: thionyl chloride
4: sodium carbonate / acetonitrile / 5 h / |Reflux
View Scheme
参考文献
Harit, Tariq; Malek, Fouad; Bali, Brahim El; Khan, Ajmal; Dalvandi, Kourosh; Marasini, Bishnu P.; Noreen, Shagufta; Malik, Rizwana; Choudhary, M. Iqbal; Khan, Sadia
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 2772 - 2778,7
反应条件
potassium hydroxide in ethanol; water
参考文献
Warner-Lambert Company
Patent: US4469868 A1, 1984 ;
参考文献
v. Auwers; Hollmann
Chemische Berichte, 1926 , vol. 59, p. 606,1296
参考文献
v. Auwers; Hollmann
Chemische Berichte, 1926 , vol. 59, p. 606,1296
参考文献
Skinner, Philip J.; Cherrier, Martin C.; Webb, Peter J.; Shin, Young-Jun; Gharbaoui, Tawfik; Lindstrom, Andrew; Hong, Vu; Tamura, Susan Y.; Dang, Huong T.; Pride, Cameron C.; Chen, Ruoping; Richman, Jeremy G.; Connolly, Daniel T.; Semple, Graeme
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 20 p. 5620 - 5623
反应条件
1.1: water; sodium hydroxide / methanol / 4 h / Reflux
1.2: pH 2 / Acidic conditions
2.1: sulfuric acid, fuming; nitric acid / 19 h / -5 - 60 °C
View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
