1: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C 2: 4.46 g / Et3N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / CH2Cl2 / 18 h / 20 °C 3: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C 4: 435 mg / Et3N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / dimethylformamide / 18 h / 20 °C 5: 99 percent / H2 / 10 percent Pd/C / dimethylformamide / 18 h / 20 °C 6: 6N HCl / 18 h / 105 °C View Scheme

1: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C 2: 4.46 g / Et3N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / CH2Cl2 / 18 h / 20 °C 3: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C 4: 435 mg / Et3N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / dimethylformamide / 18 h / 20 °C 5: 99 percent / H2 / 10 percent Pd/C / dimethylformamide / 18 h / 20 °C 6: 51 percent / Et3N; SO3*pyridine / dimethylsulfoxide / 1 h / 20 °C 7: 2.3 mg / NaBH4 / methanol / 20 °C 8: 6N HCl / 18 h / 105 °C View Scheme