N4-(3-氯-4-氟苯基)-7-(2-甲氧基乙氧基)-4,6-喹唑啉二胺合成路线 （共 2 条）
反应条件
1: With hydrogenchloride; iron in ethanol; water
2 h; Heating / reflux;
2: With sodium hydroxide in ethanol; water
T=0°C; pH=11;
参考文献
Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2009/76022 A1, 2009 ;
Location in patent: Page/Page column 77 ;
US 20090076022 A1
反应条件
1.1: sodium hydride / dimethyl sulfoxide / 2 h / 40 °C / Cooling with ice
1.2: 16 h / 40 - 50 °C
2.1: acetic acid; iron / 4 h / Reflux
View Scheme
参考文献
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD.
Patent: US2012/165352 A1, 2012 ;
