N-{[(2-甲基-2-丙基)氧基]羰基}苯丙氨酰蛋氨酸甲酯合成路线 （共 4 条）
反应条件
hydrogenchloride; acetic acid; methoxybenzene 1.5 h;
参考文献
De Figueiredo, Renata Marcia; Coudray, Laetitia; Dubois, Joelle
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 20 p. 3299 - 3309
反应条件
1: 90 percent / 1.5 N HCl/AcOH 2: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h 3: 95 percent / 1.5 N HCl/AcOH / 1 h 4: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h 5: 86 percent / 0.5 M NaOH / acetone / 1.5 h 6: 90 percent / 1.3 M HCl/AcOH / 1 h View Scheme
参考文献
Sharma, S. D.; Mathur, K. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 3 p. 227 - 229
反应条件
1: 90 percent / 1.5 N HCl/AcOH
2: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
3: 95 percent / 1.5 N HCl/AcOH / 1 h
4: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
5: 86 percent / 0.5 M NaOH / acetone / 1.5 h
View Scheme
参考文献
Masiukif.wicx, Elzbieta; Rzeszotarska, Barbara
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1672 - 1675
反应条件
sodium hydroxide in 1,4-dioxane; water
1 h; Ambient temperature;
参考文献
Van Nispen; Greven
Recueil des Travaux Chimiques des Pays Bas, 1982 , vol. 101, # 12 p. 451 - 455
