(2S)-2-环己基-N-(2-吡嗪基羰基)甘氨酰-3-甲基-L-缬氨酸甲酯合成路线 （共 4 条）
反应条件
sodium hydroxide in methanol
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
1: 100 percent / aq. NaOH / methanol 2: 100 percent / HOAt; DCC / CH2Cl2; tetrahydrofuran 3: 100 percent / aq. NaOH View Scheme
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
1.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C 1.2: pH 3.5 2.1: dichloromethane / 72 h / 20 °C 3.1: potassium carbonate; methanol / 0.5 h / 20 °C 3.2: 20 °C View Scheme
反应条件
Multi-step reaction with 2 steps 1.1: sodium hydroxide / tetrahydrofuran; methanol / 0 - 20 °C1.2: pH 3.52.1: dichloromethane / 72 h / 20 °C
参考文献
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG; RUIJTER, Eelco; ORRU, Romano; ZNABET, Anass; POLAK, Marloes; TURNER, Nicholas Patent: WO2011/103932 A1, 2011 ;
