(1S,3aR,6aS)-(2S)-2-环己基-N-(吡嗪基羰基)甘氨酰-3-甲基-L-缬氨酰八氢环戊二烯并[c]吡咯-1-羧酸乙酯合成路线 (共 2 条)
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
1: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C 2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / |Cooling with ice 3: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / |Cooling with ice View Scheme