(1S,3aR,6aS)-(2S)-2-环己基-N-(2-吡嗪基羰基)甘氨酰-3-甲基-L-缬氨酰八氢环戊并[c]吡咯-1-羧酸合成路线 （共 12 条）
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
hydrogenchloride; water in formic acid T=0°C; 3.3 h; Product distribution / selectivity;
参考文献
Tanoury, Gerald J.; Chen, Minzhang; Cochran, John E.
Patent: US2007/87973 A1, 2007 ;
Location in patent: Page/Page column 21; 48-49 ;
反应条件
1: 100 percent / HOAt; DCC / CH2Cl2; tetrahydrofuran 2: 100 percent / aq. NaOH View Scheme
参考文献
SANDOZ AG; FELZMANN, Wolfgang; BRUNNER, Stefanie; WILHELM, Thorsten
Patent: WO2013/135870 A1, 2013 ;
反应条件
1: HOBt; EDCl 2: 100 percent / aq. NaOH / methanol 3: 100 percent / HOAt; DCC / CH2Cl2; tetrahydrofuran 4: 100 percent / aq. NaOH View Scheme
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
1: 30 percent / HOBt; EDCl / tetrahydrofuran 2: HCl / dioxane; tetrahydrofuran 3: HOBt; EDCl 4: 100 percent / aq. NaOH / methanol 5: 100 percent / HOAt; DCC / CH2Cl2; tetrahydrofuran 6: 100 percent / aq. NaOH View Scheme
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
1: 30 percent / HOBt; EDCl / tetrahydrofuran 2: HCl / dioxane; tetrahydrofuran 3: HOBt; EDCl 4: 100 percent / aq. NaOH / methanol 5: 100 percent / HOAt; DCC / CH2Cl2; tetrahydrofuran 6: 100 percent / aq. NaOH View Scheme
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
1: HCl / dioxane; tetrahydrofuran 2: HOBt; EDCl 3: 100 percent / aq. NaOH / methanol 4: 100 percent / HOAt; DCC / CH2Cl2; tetrahydrofuran 5: 100 percent / aq. NaOH View Scheme
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
1: 100 percent / aq. NaOH / methanol 2: 100 percent / HOAt; DCC / CH2Cl2; tetrahydrofuran 3: 100 percent / aq. NaOH View Scheme
参考文献
Yip, Yvonne; Victor, Frantz; Lamar, Jason; Johnson, Robert; Wang, Q. May; Glass, John I.; Yumibe, Nathan; Wakulchik, Mark; Munroe, John; Chen, Shu-Hui
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 5007 - 5011
反应条件
1: copper dichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 22 h / 0 - 20 °C 2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
SANDOZ AG; FELZMANN, Wolfgang; BRUNNER, Stefanie; WILHELM, Thorsten
Patent: WO2013/135870 A1, 2013 ;
反应条件
1: diisopropyl-carbodiimide; 4-methyl-morpholine; copper dichloride / N,N-dimethyl-formamide / 5 h / 20 °C 2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
SANDOZ AG; FELZMANN, Wolfgang; BRUNNER, Stefanie; WILHELM, Thorsten
Patent: WO2013/135870 A1, 2013 ;
