(S)-2-(苄基氨基)-2-苯乙酸合成路线 （共 7 条）
反应条件
hydrogen; palladium on activated charcoal in acetic acid 24 h;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 22 p. 3747 - 3757
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=90°C; 4 h;
参考文献
Ashwood, Michael S.; Cottrell, Ian F.; Davies, Antony J.
Tetrahedron Asymmetry, 1997 , vol. 8, # 6 p. 957 - 963
反应条件
1: With sodium hydroxide in water
T=20°C; Schotten-Baumann Reaction;
2: With sodium tetrahydroborate in water
T=20°C; Schotten-Baumann Reaction;
参考文献
Huy, Peter H.; Westphal, Julia C.; Koskinen, Ari M.P.
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 369 - 383
反应条件
sodium tetrahydroborate
T=0°C; 0.5 h;
参考文献
Dondoni; Perrone
Synthesis, 1993 , # 11 p. 1162 - 1176
反应条件
1: NaOH / methanol / 18 h / Ambient temperature
2: NaBH4 / 0.5 h / 0 °C
View Scheme
参考文献
Dondoni; Perrone
Synthesis, 1993 , # 11 p. 1162 - 1176
反应条件
1.1: lithium hydroxide hydrate / methanol / 0.33 h / 20 °C
1.2: 1 h
2.1: sodium tetrahydroborate / methanol / 0.5 h
View Scheme
参考文献
Harris, Tyler L.; Worthington, Roberta J.; Melander, Christian
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4516 - 4519
反应条件
sodium hydroxide in tetrahydrofuran; water
T=0 - 20°C; 20.75 h; Overall yield = 84 percent; Overall yield = 20.84 g;
参考文献
Huy, Peter H.; Koskinen, Ari M. P.
Organic Letters, 2013 , vol. 15, # 20 p. 5178 - 5181
