ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET: RPKPQQFFGLM合成路线 （共 14 条）
反应条件
1: 63 percent / thermolysin / ethyl acetate; various solvent(s) / 20 h / 37 °C
2: HBr, glacial AcOH
4: HCl, AcOH
View Scheme
参考文献
Kuhl, Peter; Doering, Guenter; Neubert, Klaus; Jakubke, Hans-Dieter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 423 - 430
反应条件
1: 1.) Et3N, 2.) hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / 1.) CH2Cl2, 0.5 h, 2.) CH2Cl2, 16 h
2: 81 percent / ammonia / methanol / 48 h / Ambient temperature
View Scheme
参考文献
Lipkowski, Andrzej W.; Majewski, Tadeusz; Drabarek, Stefania
Polish Journal of Chemistry, 1980 , vol. 54, # 2 p. 373 - 374
反应条件
1: 92 percent / N(C2H5)3 / dimethylformamide / 1.) 30 min., 0 deg C; 2.) 1.5 h, room temp.
2: 1.1 M HCl in acetic acid / 0.42 h / 20 °C
View Scheme
参考文献
Neubert; Hartrodt; Koch; et al.
Pharmazie, 1981 , vol. 36, # 1 p. 10 - 12
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide
1.) DMF, 0.5 h, 2.) DMF, RT, 16 h; Yield given. Multistep reaction;
参考文献
Lipkowski, Andrzej W.; Majewski, Tadeusz; Drabarek, Stefania
Polish Journal of Chemistry, 1980 , vol. 54, # 9 p. 1707 - 1712
