3-氟-4-甲氧基苯甲酸合成路线 （共 23 条）
反应条件
sulfuric acid; water T=110°C; 4 h;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0172 ;
反应条件
1: With potassium hydroxide; water in methanol 1 h; Heating / reflux; 2: With hydrogenchloride in water pH=2;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 371 ;
反应条件
1: 1-bromo-3-fluoro-4-methoxybenzene With magnesium; lithium chloride in tetrahydrofuran 2 h; Reflux; 2: carbon dioxide in tetrahydrofuran T=-70 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; water pH=0;
参考文献
Ziobro, Dorota; Dziaduszek, Jerzy; Filipowicz, Marek; Dabrowski, Roman; Czu, Joanna; Urban, Stanislaw
Molecular Crystals and Liquid Crystals, 2009 , vol. 502, p. 258 - 271
反应条件
sodium dichromate; sulfuric acid
参考文献
Hansen
Journal of the American Chemical Society, 1937 , vol. 59, p. 280
反应条件
potassium hydroxide; ethanol in water 25 h; Heating;
参考文献
Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24
反应条件
diethyl ether anschliessend Behandeln mit CO2;
参考文献
Morgan et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 5658
反应条件
diethyl ether; magnesium; benzene anschliessend Behandeln mit CO2;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
1: 1-methyl-2-pyrrolidinone / 2 h / 180 °C 2: sodium hydroxide / H2O / 60 h 3: 64 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating View Scheme
参考文献
Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24
反应条件
1: 69 percent / bromine / CHCl3 / 0.01 h 2: 1-methyl-2-pyrrolidinone / 2 h / 180 °C 3: sodium hydroxide / H2O / 60 h 4: 64 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating View Scheme
参考文献
Yerande, Swapnil G.; Shendage, Deepak M.; Wakchaure, Prasad B.; Phadtare, Ganesh R.; Bhoite, Madhavrao Y.; Gangopadhyay, Ashok Kumar; Nagarajan, Kuppuswamy; Rupp, Richard Helmut
Tetrahedron Letters, 2014 , vol. 55, # 15 p. 2426 - 2429
反应条件
1: sodium hydroxide / H2O / 60 h 2: 64 percent / ethanol, potassium hidroxide / H2O / 25 h / Heating View Scheme
参考文献
Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24
