3-氟-4-甲氧基苯甲酸合成路线 （共 23 条）
反应条件
sodium hydroxide; potassium chloride; potassium hexacyanoferrate(III) in methanol; water T=30°C; further temperature; activation energy; Thermodynamic dataKinetics;
参考文献
Yerande, Swapnil G.; Shendage, Deepak M.; Wakchaure, Prasad B.; Phadtare, Ganesh R.; Bhoite, Madhavrao Y.; Gangopadhyay, Ashok Kumar; Nagarajan, Kuppuswamy; Rupp, Richard Helmut
Tetrahedron Letters, 2014 , vol. 55, # 15 p. 2426 - 2429
反应条件
water; silver(l) oxide
参考文献
Lock
Monatshefte fuer Chemie, 1955 , vol. 86, p. 511,515
反应条件
1: aqueous formaldehyde / Einleiten von HCl 2: hexamethylenetetramine; aqueous ethanol 3: Ag2O; H2O View Scheme
参考文献
Lock
Monatshefte fuer Chemie, 1955 , vol. 86, p. 511,515
反应条件
1: hexamethylenetetramine; aqueous ethanol 2: Ag2O; H2O View Scheme
参考文献
Lock
Monatshefte fuer Chemie, 1955 , vol. 86, p. 511,515
反应条件
durch Austausch der Nitrogruppe gegen Fluor;
参考文献
Paterno; Oliveri
Gazzetta Chimica Italiana, 1882 , vol. 12, p. 89
参考文献
Schiemann; Winkelmueller
Journal fuer Praktische Chemie (Leipzig), 1932 , vol. <2> 135, p. 101,113
反应条件
thionyl chloride in dichloromethane; N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Abuhaie, Cristina-Maria; Bicu, Elena; Rigo, Benoit; Gautret, Philippe; Belei, Dalila; Farce, Amaury; Dubois, Joelle; Ghinet, Alina
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 147 - 152
反应条件
boron tribromide in dichloromethane T=-78 - 20°C;
参考文献
Svensson, Anette; Fex, Tomas; Kihlberg, Jan
Tetrahedron Letters, 1996 , vol. 37, # 42 p. 7649 - 7652
反应条件
1: 96 percent / BBr3 / CH2Cl2 / -78 - 20 °C 2: 86 percent / CH2Cl2; methanol View Scheme
参考文献
Minor; Vanderwerf
Journal of Organic Chemistry, 1952 , vol. 17, p. 1425,1429
反应条件
1: thionyl chloride; DMF / 1 h / Heating 2: 46.5 g / pyridine / CH2Cl2 / 0 °C 3: 81 percent / p-toluenesulfonic acid monohydrate; p-xylene / 3 h / Heating 4: 93 percent / BBr3 / CH2Cl2 / -78 - 20 °C 5: 72 percent / dichlorobis(tri-o-tolylphosphine)palladium (II) / 1,2-diethoxy-ethane / 48 h / 115 °C View Scheme
参考文献
Malamas, Michael S.; Manas, Eric S.; McDevitt, Robert E.; Gunawan, Iwan; Xu, Zhang B.; Collini, Michael D.; Miller, Chris P.; Dinh, Tam; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5021 - 5040
