3-氟-4-甲氧基苯甲酸合成路线 （共 23 条）
反应条件
1: nitric acid / -5 °C 2: hydrogen chloride 3: platinum; methanol / Hydrogenation View Scheme
参考文献
English; Mead; Niemann
Journal of the American Chemical Society, 1940 , vol. 62, p. 350,353
反应条件
1: With triethylamine; isobutyl chloroformate in tetrahydrofuran
T=0°C; 1 h;
2: With ammonia in tetrahydrofuran
T=20°C; 15 h;
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 371 ;
反应条件
(i) SOCl2, (ii) /BRN= 1734159/, aq. KOH; Multistep reaction;
参考文献
Sterling Drug
Patent: US4009208 , 1977 ;
Chem.Abstr., 1977 , vol. 86, # 171114
