2-溴-4'-氟苯乙酮合成路线 （共 119 条）
反应条件
in ethanol T=80°C; 3 h;
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
反应条件
in ethanol 0.5 h; Heating / reflux;
参考文献
Sanofi-Aventis Deutschland GmbH
Patent: EP1741709 A1, 2007 ;
Location in patent: Page/Page column 38-39; 41; 43 ;
反应条件
S4N4*SbCl5 in toluene 3.5 h; Heating;
参考文献
Kim, Kil-Joong; Kim, Kyongtae
Tetrahedron Letters, 1997 , vol. 38, # 24 p. 4227 - 4230
反应条件
in acetic acid 4 h; Heating;
参考文献
Jendralla; Granzer; V Kerekjarto; Krause; Schacht; Baader; Bartmann; Beck; Bergmann; Kessler; Wess; Chen; Granata; Herchen; Kleine; Schussler; Wagner
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 2962 - 2983
反应条件
sodium ethanolate in ethanol
参考文献
Kaspersen, Svein Jacob; Hoff, Bard Helge; Sundby, Eirik; Charnock, Colin
Bioorganic Chemistry, 2012 , vol. 44, p. 35 - 41,7
反应条件
nBu4NPF6 in methanol T=20°C; 0.233333 h;
参考文献
Kocabas, Erdal; Sariguney, Ahmet Burak; Coskun, Ahmet
Heterocycles, 2010 , vol. 81, # 12 p. 2849 - 2854
反应条件
1: in ethanol; water T=20°C; 2 h; 2: With hydrogenchloride in ethanol; water pH=5 - 6;
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2006/63732 A1, 2006 ;
Location in patent: Page/Page column 30 ;
反应条件
tetrabutylammomium bromide in water; toluene T=20°C; chemoselective reaction;
参考文献
Patil, Shivaraj P.; Kanawade, Shrikant B.; Shinde, Madhukar P.; Toche, Raghunath B.
Indian Journal of Heterocyclic Chemistry, 2011 , vol. 21, # 1 p. 33 - 36
参考文献
Kamila, Sukanta; Zhu, Dunming; Biehl, Edward R.; Hua, Ling
Organic Letters, 2006 , vol. 8, # 20 p. 4429 - 4431
反应条件
1: 0.2 h / 20 °C / |Ionic liquid 2: sodium cyanoborohydride; acetic acid / 24 h / 20 °C 3: hydrazine hydrate / water / 3 h / 60 °C View Scheme
参考文献
Schrittwieser, Joerg H.; Coccia, Francesca; Kara, Selin; Grischek, Barbara; Kroutil, Wolfgang; D'Alessandro, Nicola; Hollmann, Frank
Green Chemistry, 2013 , vol. 15, # 12 p. 3318 - 3331
