2-溴-4'-氟苯乙酮合成路线 （共 119 条）
反应条件
T=170 - 180°C; Inert atmosphere;
参考文献
Kumar, Sanjeev; Jaller, Daniel; Patel, Bhumika; LaLonde, Judith M.; DuHadaway, James B.; Malachowski, William P.; Prendergast, George C.; Muller, Alexander J.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 16 p. 4968 - 4977
反应条件
formamide in ethyl acetate
参考文献
Bristol-Myers Squibb Company
Patent: US2011/263494 A1, 2011 ;
US 20110263494 A1
反应条件
triethylamine in acetone T=-10 - 20°C;
参考文献
Yamada, Kazuhiro; Yoshizawa, Yuko; Oh, Keimei
Molecules, 2012 , vol. 17, # 4 p. 4460 - 4473
反应条件
7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL in acetone Cyclization; Heating;
参考文献
Habermann, Joerg; Ley, Steven V.; Smits, Rene
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 17 p. 2421 - 2423
反应条件
1: 69 percent / dioxane / 4 h / Ambient temperature 2: 9 percent / BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C View Scheme
参考文献
Kihara, Masaru; Kashimoto, Minoru; Kobayashi, Yoshimaro
Tetrahedron, 1992 , vol. 48, # 1 p. 67 - 78
参考文献
Mondeshka; Angelova; Tancheva; Ivanov; Daleva; Ivanova
Farmaco, 1994 , vol. 49, # 7-8 p. 475 - 480
反应条件
1: sodium tetrahydroborate / methanol / 0 - 20 °C 2: potassium carbonate / methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 40 p. 16001 - 16012
反应条件
1: sodium tetrahydroborate / methanol / 0 - 20 °C 2: potassium carbonate / methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 40 p. 16001 - 16012
反应条件
1: sodium tetrahydroborate / methanol / 0 - 20 °C 2: potassium carbonate / methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 40 p. 16001 - 16012
反应条件
1.1: acetone / Reflux 2.1: hydrogenchloride / water / 1 h / Reflux 3.1: trichlorophosphate / chloroform / 0 - 5 °C 3.2: 20 °C / Reflux 3.3: Cooling with ice View Scheme
参考文献
Kamal, Ahmed; Dastagiri; Ramaiah, M. Janaki; Reddy, J. Surendranadha; Bharathi, E. Vijaya; Srinivas, Chatla; Pushpavalli; Pal, Dhananjaya; Pal-Bhadra, Manika
ChemMedChem, 2010 , vol. 5, # 11 p. 1937 - 1947
