2-溴-4'-氟苯乙酮合成路线 （共 119 条）
反应条件
1: in ethanol
16 h; Heating / reflux;
2: With ammonia in ethanol; water
Alkaline conditions;
参考文献
ARQULE, INC.
Patent: WO2006/44869 A1, 2006 ;
Location in patent: Page/Page column 69; 132-133 ;
WO 2006/044869 A1
反应条件
1: 79 percent / tetrahydrofuran / 24 h / 50 °C
2: 87 percent / methanol / 3 h / Heating
3: 84 percent / 2M Na2CO3 / CHCl3 / 0.33 h / 20 °C
View Scheme
参考文献
Kamal, Ahmed; Dastagiri; Ramaiah, M. Janaki; Reddy, J. Surendranadha; Bharathi, E. Vijaya; Srinivas, Chatla; Pushpavalli; Pal, Dhananjaya; Pal-Bhadra, Manika
ChemMedChem, 2010 , vol. 5, # 11 p. 1937 - 1947
反应条件
1: butan-2-one / 2 h / Heating
2: 2-methoxy-ethanol / 1 h / Heating
View Scheme
参考文献
Mase, Toshiyasu; Arima, Hideki; Tomioka, Kenichi; Yamada, Toshimitsu; Murase, Kiyoshi
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 386 - 394
反应条件
in ethanol
T=70°C; 18 h;
参考文献
Buu-Hoi,N.P. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 1277 - 1279
反应条件
1: NaOEt
2: aq. HCl; AcOH / 20 °C
View Scheme
参考文献
Maeda, Yutaka; Nakano, Masato; Sato, Hideyuki; Miyazaki, Yasushi; Schweiker, Stephanie L.; Smith, Jeffery L.; Truesdale, Anne T.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3907 - 3911
反应条件
1: NaOEt
2: aq. HCl; AcOH / 20 °C
3: 200 °C
View Scheme
参考文献
Maeda, Yutaka; Nakano, Masato; Sato, Hideyuki; Miyazaki, Yasushi; Schweiker, Stephanie L.; Smith, Jeffery L.; Truesdale, Anne T.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3907 - 3911
参考文献
Bahner et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 3960
反应条件
sodium hydroxide in ethanol; water
参考文献
Maeda, Yutaka; Nakano, Masato; Sato, Hideyuki; Miyazaki, Yasushi; Schweiker, Stephanie L.; Smith, Jeffery L.; Truesdale, Anne T.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3907 - 3911
参考文献
Bahner et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 3960
反应条件
1: benzene / 10 h
2: 62 percent / N, N-dimethylaniline / 7 h / Heating
View Scheme
参考文献
Bansal, R. K.; Bhagchandani, Gope
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 9 p. 801 - 802
