B-chloro-diisopinocampheylborane in tetrahydrofuran T=64°C; other 4-substituted acetophenones; other oxidative workup; var. temps; Product distributionMechanism;
参考文献
Mathre, David J.; Thompson, Andrew S.; Douglas, Alan W.; Hoogsteen, Karst; Caroll, James D.; et al.
Journal of Organic Chemistry, 1993 , vol. 58, # 10 p. 2880 - 2888
1: 1-fluoro-4-acetyl-benzene With aluminum oxide; sodium tetrahydroborate in hexane T=40°C; 3 h; 2: 2-acetyloxy-1-propene With Lipase 'Amano' PS-C II in hexane T=25°C; 10 h;
1: With sodium hydride in tetrahydrofuran T=20°C; 72 h; 2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water 3: With sodium hydroxide in water T=0°C; pH=11 - 12;
参考文献
AVIGEN, INC.
Patent: WO2007/146087 A2, 2007 ;
Location in patent: Page/Page column 54 ;
