1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 60 °C / |Reflux
2.1: toluene / 14 h / 100 °C
2.2: 3 h / 80 °C
3.1: sodium hydroxide; water / ethanol / 14 h / 70 °C
View Scheme
potassium carbonate in N,N-dimethyl acetamide
Heating;
参考文献
Gorczynski, Michael J.; Leal, Rachel M.; Mooberry, Susan L.; Bushweller, John H.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1029 - 1036