1-环丙基-4-甲氧基苯合成路线 （共 29 条）
反应条件
1: With nitrosyl chloride in dichloromethane T=-40°C; 2 h; 2: With sodium carbonate in water T=0°C;
参考文献
Russian Journal of Organic Chemistry, , vol. 42, # 2 p. 249 - 255
反应条件
1: 42 percent / NOCl*2SO3 / CH2Cl2 / 2 h / 0 °C 2: 68 percent / NOCl*2SO3 / CH2Cl2 / 20 h / 0 °C View Scheme
参考文献
Bondarenko; Gavrilova; Kazantseva; Tikhanushkina; Nifant'ev; Saginova; Zyk
Russian Journal of Organic Chemistry, 2007 , vol. 43, # 4 p. 564 - 570
反应条件
1: With nitrosyl chloride in dichloromethane T=-40°C; 2 h; 2: With sodium carbonate in water T=0°C;
参考文献
Russian Journal of Organic Chemistry, , vol. 42, # 2 p. 249 - 255
反应条件
1: 42 percent / NOCl*2SO3 / CH2Cl2 / 2 h / 0 °C 2: 68 percent / NOCl*2SO3 / CH2Cl2 / 20 h / 0 °C View Scheme
参考文献
Bondarenko; Gavrilova; Kazantseva; Tikhanushkina; Nifant'ev; Saginova; Zyk
Russian Journal of Organic Chemistry, 2007 , vol. 43, # 4 p. 564 - 570
反应条件
diethylzinc in toluene
T=50°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/19151 A1, 2005 ;
Location in patent: Page/Page column 131 ;
WO 2005/019151 A1
反应条件
potassium carbonate; palladium diacetate in water
T=100°C; Suzuki-Miyaura cross-coupling; 24 h;
参考文献
Molander, Gary A.; Gormisky, Paul E.
Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7481 - 7485
反应条件
palladium diacetate; zinc dibromide; [(t-Bu)3PH]BF4 in tetrahydrofuran
T=20 - 25°C; 2.5 h; Inert atmosphere;
参考文献
Shu, Chutian; Sidhu, Kanwar; Zhang, Li; Wang, Xiao-Jun; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6677 - 6680
反应条件
indium in acetonitrile
T=25°C; 5 h;
参考文献
Virender; Jain, Suman L.; Sain, Bir
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 37 - 38
反应条件
potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); all-cis-tetrakis[(diphenylphosphanyl)methyl]cyclopentane in xylene
T=130°C; Suzuki cross-coupling; 20 h;
参考文献
Lemhadri, Mhamed; Doucet, Henri; Santelli, Maurice
Synthetic Communications, 2006 , vol. 36, # 1 p. 121 - 128
反应条件
1: di-tert-butoxy(cyclopropyl)silanol With boron trifluoride diethyl etherate
0.25 h; Inert atmosphere;
2: 1-bromo-4-methoxy-benzene With tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride in tetrahydrofuran
T=100°C; Hiyama-Denmark cross-coupling; 16 h; Inert atmosphere;
参考文献
Beaulieu, Louis-Philippe B.; Delvos, Lukas B.; Charette, Andre B.
Organic Letters, 2010 , vol. 12, # 6 p. 1348 - 1351
