1-环丙基-4-甲氧基苯合成路线 （共 29 条）
反应条件
1: ethylmagnesium bromide With zirconocene dichloride in tetrahydrofuran
T=-78 - 0°C; 0.416667 h;
2: 4-methoxy-benzaldehyde in tetrahydrofuran
T=20°C;
3: With titanium tetrachloride in dichloromethane
T=20°C; 0.333333 h;
参考文献
Gandon, Vincent; Bertus, Philippe; Szymoniak, Jan
European Journal of Organic Chemistry, 2000 , # 22 p. 3713 - 3719
反应条件
palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran; water
T=100°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphereSealed tubesolid phase reaction;
参考文献
Colombel, Virginie; Presset, Marc; Oehlrich, Daniel; Rombouts, Frederik; Molander, Gary A.
Organic Letters, 2012 , vol. 14, # 7 p. 1680 - 1683
反应条件
1: With CoBr2(1,2-bis(diphenylphosphino)ethane); zinc(II) iodide; zinc in dichloromethane
T=20°C; Diels-Alder reaction; Inert atmosphere;
2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in benzene
T=20°C; 1 h; Inert atmosphere; regioselective reaction;
参考文献
Arndt, Marion; Hilt, Gerhard; Khlebnikov, Alexander F.; Kozhushkov, Sergei I.; De Meijere, Armin
European Journal of Organic Chemistry, 2012 , # 16 p. 3112 - 3121
反应条件
Pd(P(o-Tol)3)2; CyPF-tBu in tetrahydrofuran; toluene
T=80°C; Kumada coupling; 4 h;
参考文献
Limmert, Michael E.; Roy, Amy H.; Hartwig, John F.
Journal of Organic Chemistry, 2005 , vol. 70, # 23 p. 9364 - 9370
反应条件
palladium diacetate; zinc dibromide; [(t-Bu)3PH]BF4 in tetrahydrofuran
T=20 - 25°C; 2.5 h; Inert atmosphere;
参考文献
Shu, Chutian; Sidhu, Kanwar; Zhang, Li; Wang, Xiao-Jun; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6677 - 6680
反应条件
potassium phosphate; palladium diacetate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in water; tert-butyl alcohol
T=110°C; Inert atmosphere;
参考文献
Molander, Gary A.; Beaumard, Floriane; Niethamer, Terren K.
Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 8126 - 8130
反应条件
1: propargyl bromide With 9-borabicyclo[3.3.1]nonane dimer in tetrahydrofuran
dihydroboration; 2 h; Heating;
2: With sodium hydroxide in tetrahydrofuran
T=20°C; Hydrolysis; 1 h;
3: 1-bromo-4-methoxy-benzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=65°C; Suzuki-Miyaura coupling; 8 h;
参考文献
Soderquist, John A.; Huertas, Ramon; Leon-Colon, Gisela
Tetrahedron Letters, 2000 , vol. 41, # 22 p. 4251 - 4255
反应条件
n-tridecane; [NiCl2(PMe3)2] in tetrahydrofuran
T=60°C;
参考文献
Miller, Joseph A.; Dankwardt, John W.
Tetrahedron Letters, 2003 , vol. 44, # 9 p. 1907 - 1910
反应条件
in various solvent(s)
参考文献
Crist, DeLanson R.; Jordan, Guy J.; Moore, Donald W.; Hashmall, Joseph A.; Borsetti, Arnold P.; Turujman, Saleh A.
Journal of the American Chemical Society, 1983 , vol. 105, # 13 p. 4136 - 4142
反应条件
1: cyclopropyl-magnesium bromide With lithium thiophenoxide in tetrahydrofuran
T=20 - 60°C; 1.5 h;
2: 2-methoxy 5-cyanobenzene With [NiCl2(PMe3)2] in tetrahydrofuran
T=60°C; 15 h;
参考文献
Miller, Joseph A.; Dankwardt, John W.; Penney, Jonathan M.
Synthesis, 2003 , # 11 p. 1643 - 1648
