反应条件
1: 2-methylcyclopropyldiphenylsulfonium trifluomethanesulfonate With potassium hexamethylsilazane in tetrahydrofuran T=-70°C; 0.5 h; Inert atmosphere; 2: 1-(1,1-diphenylmethyl)azetidin-3-one in tetrahydrofuran T=-40°C; 4 h; 3: With lithium iodide in tetrahydrofuran T=20 - 50°C;
参考文献
TRIUS THERAPEUTICS INC.; LAWRENCE LIVERMORE NATIONAL SECURITY, LLC; BENSEN, Daniel; BORCHARDT, Allen; CHEN, Zhiyong; FINN, John, M.; LAM, Thanh, To; LEE, Suk, Joong; LI, Xiaoming; TARI, Leslie, William; TENG, Min; TRZOSS, Michael; ZHANG, Junhu; JUNG, Michael, E.; LIGHTSTONE, Felice, C.; WONG, Sergio, E.; NGUYEN, Toan, B.
Patent: WO2014/43272 A1, 2014 ;
Location in patent: Paragraph 0481; 0482; 0483 ;