7-硝基-3,4-二氢-2H-1-萘酮合成路线 （共 23 条）
反应条件
1: tin (II)-chloride; hydrochloric acid 2: Diazotization.Behandeln mit Kupfer(I)-chlorid View Scheme
参考文献
v. Braun
Justus Liebigs Annalen der Chemie, 1927 , vol. 451, p. 53
反应条件
1: 92.1 percent / NaBH4 / aq. ethanol / 1.5 h / Ambient temperature 2: 91.3 percent / Amberlyst 15 cation-exchange resin / benzene / 2 h / Heating 3: 89.5 percent / 85percent m-chloroperoxybenzoic acid / CHCl3 / 0.67 h / Heating 4: 83 percent / ZnI2 / benzene / 15 h / Ambient temperature View Scheme
参考文献
Nichols, David E.; Cassady, John M.; Persons, Paul E.; Yeung, Ming C.; Clemens, James A.; Smalstig, E. Barry
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2128 - 2134
反应条件
1: With BH3*SMe2 in tetrahydrofuran T=20°C; 15 h; 2: With methanol in tetrahydrofuran T=0°C;
参考文献
Gross, Michael F.; Castle, Neil A.; Zou, Anruo; Wickenden, Alan D.; Yu, Weifeng; Spear, Kerry L.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3063 - 3066
反应条件
1,2,3,4-tetrahydro-naphthalene; hydrogen; nickel T=120°C; unter Druck;
参考文献
v. Braun
Justus Liebigs Annalen der Chemie, 1927 , vol. 451, p. 53
参考文献
ICI Americas Inc.
Patent: US5095038 A1, 1992 ;
反应条件
hydrogenchloride; hydrogen; palladium in sodium hydroxide; ethanol; water
参考文献
Syntex (U.S.A.) Inc.
Patent: US5475003 A1, 1995 ;
反应条件
(i) NBS, PhCO3H, CCl4, (ii) NaOAc, AcOH; Multistep reaction;
参考文献
Shand,A.J.; Thomson,R.H.
Tetrahedron, 1963 , vol. 19, p. 1919 - 1937
反应条件
1: tin (II)-chloride; hydrochloric acid
2: sodium; alcohol
3: diluted alcohol; hydroxylamine
4: sulfuric acid / 70 °C
View Scheme
参考文献
v. Braun
Justus Liebigs Annalen der Chemie, 1927 , vol. 451, p. 53
反应条件
1: (i) NBS, PhCO3H, CCl4, (ii) NaOAc, AcOH
2: K2CO3 / acetone
3: (i) H2, Adams catalyst, AcOEt, (ii) aq. NaNO2, H2SO4, (iii) aq. CuSO4
View Scheme
参考文献
Shand,A.J.; Thomson,R.H.
Tetrahedron, 1963 , vol. 19, p. 1919 - 1937
反应条件
sodium azide; sulfuric acid; acetic acid
T=0 - 50°C; Schmidt Reaction; 4 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/4959 A1, 2007 ;
Location in patent: Page/Page column 50 ;
WO 2007/004959 A1
