2,2',6,6'-四甲基联苯合成路线 （共 23 条）
反应条件
palladium diacetate; triphenylphosphine; cesium fluoride in ethylene glycol dimethyl ether
T=70°C; Suzuki coupling; 6 h;
参考文献
Castanet, Anne-Sophie; Colobert, Francoise; Broutin, Pierre-Emmanuel; Obringer, Michel
Tetrahedron Asymmetry, 2002 , vol. 13, # 6 p. 659 - 665
反应条件
1: With magnesium in tetrahydrofuran
T=20°C; 3 h; Inert atmosphere;
2: With synthetic air; cobalt(II) chloride in tetrahydrofuran
T=0°C; 3 h; Inert atmosphere;
参考文献
Mayer, Matthias; Czaplik, Waldemar Maximilian; Jacobi Von Wangelin, Axel
Synlett, 2009 , # 18 p. 2919 - 2923
反应条件
hydrogenchloride
Diazotization.Behandlung der Diazoniumsalz-Loesung mit wss. H3PO2;
参考文献
Carlin
Journal of the American Chemical Society, 1945 , vol. 67, p. 928,931
反应条件
1: aqueous hydrochloric acid
2: aqueous HCl / Diazotization.Behandlung der Diazoniumsalz-Loesung mit wss. H3PO2
View Scheme
参考文献
Carlin
Journal of the American Chemical Society, 1945 , vol. 67, p. 928,931
反应条件
aluminium trichloride in benzene
参考文献
Tashiro,M.; Yamato,T.
Journal of Organic Chemistry, 1979 , vol. 44, p. 3037 - 3041
反应条件
1: Cu / 300 °C
2: AlCl3 / benzene
View Scheme
参考文献
Tashiro,M.; Yamato,T.
Journal of Organic Chemistry, 1979 , vol. 44, p. 3037 - 3041
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With Pd-PEPPSI-IPent; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
C54H80Cl2Fe2N2O4 in diethyl ether
T=100°C; 0.166667 h; Inert atmosphereMicrowave irradiation;
参考文献
Qian, Xin; Dawe, Louise N.; Kozak, Christopher M.
Dalton Transactions, 2011 , vol. 40, # 4 p. 933 - 943
反应条件
C54H80Cl2Fe2N2O4 in diethyl ether
T=100°C; 0.166667 h; Inert atmosphereMicrowave irradiation;
参考文献
Qian, Xin; Dawe, Louise N.; Kozak, Christopher M.
Dalton Transactions, 2011 , vol. 40, # 4 p. 933 - 943
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
