1: With sodium hypochlorite; water; sodium hydroxide T=30°C; 2: With hydrogenchloride in water pH=2;

1: 2,3,5-trichloro-6-iodopyridine With isopropylmagnesium chloride in tetrahydrofuran T=-75°C; 0.75 h; 2: carbon dioxide T=-75°C; Further stages.;

1.1: 89 percent / lithium diisopropylamide; iodine / tetrahydrofuran; hexane / -75 °C 2.1: 59 percent / lithium 2,2,6,6-tetramethylpiperidine; H2O / tetrahydrofuran; methanol / -100 - -75 °C 3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.75 h / -75 °C 3.2: 76 percent / -75 °C View Scheme

1.1: 59 percent / lithium 2,2,6,6-tetramethylpiperidine; H2O / tetrahydrofuran; methanol / -100 - -75 °C 2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.75 h / -75 °C 2.2: 76 percent / -75 °C View Scheme