2-(4-羟基-2-甲基苯氧基)乙酸乙酯合成路线 （共 3 条）
反应条件
1: With sodium ethanolate in ethanol
T=45°C; 1.5 h;
2: With hydrogenchloride in ethanol; water
T=20°C;
参考文献
INPHARMATICA LIMITED
Patent: WO2007/36727 A1, 2007 ;
Location in patent: Page/Page column 45 ;
WO 2007/036727 A1
反应条件
1: potassium carbonate / acetonitrile / 8 h / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / toluene-4-sulfonic acid / dichloromethane / 20 °C
3: ethanol / toluene-4-sulfonic acid / 6 h / Reflux
View Scheme
参考文献
Zhejiang Hisun Pharmaceutical Co. Ltd.
Patent: EP2330098 A1, 2011 ;
反应条件
1: 3-chloro-benzenecarboperoxoic acid / toluene-4-sulfonic acid / dichloromethane / 20 °C
2: ethanol / toluene-4-sulfonic acid / 6 h / Reflux
View Scheme
参考文献
Zhejiang Hisun Pharmaceutical Co. Ltd.
Patent: EP2330098 A1, 2011 ;
