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乙二醇
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63148-62-9
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二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
403620-92-8
合成路线
（共 9 条）
75-26-3
2-溴丙烷
+
403620-97-3
→
反应条件
403620-92-8
反应条件
potassium carbonate in dimethyl sulfoxide T=50°C; regioselective reaction;
参考文献
Montanaro, Gabriele; Bertinaria, Massimo; Rolando, Barbara; Fruttero, Roberta; Lucas, Christopher D.; Dorward, David A.; Rossi, Adriano G.; Megson, Ian L.; Gasco, Alberto
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 2107 - 2116
67-63-0
异丙醇
+
403620-97-3
→
反应条件
403620-92-8
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=20°C;
参考文献
Vandromme, Lucie; Legraverend, Michel; Kreimerman, Sergio; Lozach, Olivier; Meijer, Laurent; Grierson, David S.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 130 - 141
403620-89-3
→
反应条件
403620-92-8
反应条件
1: 97 percent / triethylamine / ethanol / 0.17 h / 60 °C 2: 77 percent / trifluoroacetic acid / CH2Cl2 / 0.17 h / 20 °C 3: 80 percent / PPh3; DIAD / tetrahydrofuran / 20 °C View Scheme
参考文献
Vandromme, Lucie; Legraverend, Michel; Kreimerman, Sergio; Lozach, Olivier; Meijer, Laurent; Grierson, David S.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 130 - 141
403620-90-6
→
反应条件
403620-92-8
反应条件
1: 77 percent / trifluoroacetic acid / CH2Cl2 / 0.17 h / 20 °C 2: 80 percent / PPh3; DIAD / tetrahydrofuran / 20 °C View Scheme
参考文献
Vandromme, Lucie; Legraverend, Michel; Kreimerman, Sergio; Lozach, Olivier; Meijer, Laurent; Grierson, David S.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 130 - 141
100-53-8
苄硫醇
→
反应条件
403620-92-8
反应条件
1: 97 percent / triethylamine / ethanol / 0.17 h / 60 °C 2: 77 percent / trifluoroacetic acid / CH2Cl2 / 0.17 h / 20 °C 3: 80 percent / PPh3; DIAD / tetrahydrofuran / 20 °C View Scheme
参考文献
Vandromme, Lucie; Legraverend, Michel; Kreimerman, Sergio; Lozach, Olivier; Meijer, Laurent; Grierson, David S.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 130 - 141
87-42-3
6-氯嘌呤
→
反应条件
403620-92-8
反应条件
1.1: 90 percent / TsOH / ethyl acetate / 65 °C 2.1: Bu3SnCl; LiTMP / tetrahydrofuran / -78 °C 2.2: I2 / tetrahydrofuran / 0.5 h / 20 °C 3.1: 82 percent / Et3N / 2 h / 60 °C 4.1: 85 percent / H2O; TFA / 20 °C 5.1: 60 percent / DEAD; Ph3P / 20 °C View Scheme
参考文献
Brun, Virginie; Legraverend, Michel; Grierson, David S.
Tetrahedron Letters, 2001 , vol. 42, # 46 p. 8161 - 8164
7306-68-5
6-氯-9-(四氢-2-吡喃基)嘌呤
→
反应条件
403620-92-8
反应条件
1.1: Bu3SnCl; LiTMP / tetrahydrofuran / -78 °C 1.2: I2 / tetrahydrofuran / 0.5 h / 20 °C 2.1: 82 percent / Et3N / 2 h / 60 °C 3.1: 85 percent / H2O; TFA / 20 °C 4.1: 60 percent / DEAD; Ph3P / 20 °C View Scheme
参考文献
Brun, Virginie; Legraverend, Michel; Grierson, David S.
Tetrahedron Letters, 2001 , vol. 42, # 46 p. 8161 - 8164
18552-90-4
2-碘-6-氯嘌呤
→
反应条件
403620-92-8
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / |Reflux; |Inert atmosphere 2: potassium carbonate / dimethyl sulfoxide / 50 °C View Scheme
参考文献
Montanaro, Gabriele; Bertinaria, Massimo; Rolando, Barbara; Fruttero, Roberta; Lucas, Christopher D.; Dorward, David A.; Rossi, Adriano G.; Megson, Ian L.; Gasco, Alberto
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 2107 - 2116
5987-76-8
→
反应条件
403620-92-8
反应条件
1.1: sulfuric acid / water / 3 h / |Reflux 1.2: pH 4.5 2.1: N-ethyl-N,N-diisopropylamine / ethanol / |Reflux; |Inert atmosphere 3.1: potassium carbonate / dimethyl sulfoxide / 50 °C View Scheme
参考文献
Montanaro, Gabriele; Bertinaria, Massimo; Rolando, Barbara; Fruttero, Roberta; Lucas, Christopher D.; Dorward, David A.; Rossi, Adriano G.; Megson, Ian L.; Gasco, Alberto
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 2107 - 2116
