5-溴-2-(三氟甲氧基)苯甲酸合成路线 （共 6 条）
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-100°C; 2 h; 2: carbon dioxide
参考文献
Schlosser, Manfred; Castagnetti
European Journal of Organic Chemistry, 2001 , # 21 p. 3991 - 3997
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With lithium diisopropyl amide in tetrahydrofuran; hexanes T=-100°C; 1.5 h; 2: carbon dioxide T=-100 - 20°C; 18.75 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2004/82779 A1, 2004 ;
Location in patent: Page 91 ;
US 20040082779 A1
反应条件
1: With sodium hydroxide in ethanol T=85°C; 18 h; Inert atmosphere; 2: With hydrogenchloride in dichloromethane; water pH=4;
参考文献
Gilead Palo Alto, Inc.
Patent: US2011/21521 A1, 2011 ;
Location in patent: Page/Page column 56; 57 ;
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane 2: carbon dioxide
参考文献
Schlosser, Manfred; Castagnetti
European Journal of Organic Chemistry, 2001 , # 21 p. 3991 - 3997
反应条件
borane-THF in tetrahydrofuran T=0 - 70°C; 18 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2004/82779 A1, 2004 ;
Location in patent: Page 91 ;
US 20040082779 A1
反应条件
sulfuric acid
Heating / reflux;
参考文献
Bayer Schering Pharma Aktiengesellschaft
Patent: EP2020404 A1, 2009 ;
Location in patent: Page/Page column 36 ;
EP 2020404 A1
