2-(3-丁炔氧基)四氢吡喃合成路线 （共 44 条）
反应条件
methanol; DOWEX 50 W-X2 cation exchange resin T=40°C; 1 h;
参考文献
Tanacs, B.; Kling, F.; Mucha, I.; Marton, J.
Acta Chimica Hungarica, 1983 , vol. 112, # 2 p. 233 - 240
反应条件
1: 4-[(tetrahydro-2H-pyran-2-yl)oxy]-1-butyne; triethylaluminum With n-butyllithium in diethyl ether; hexane T=-20 - 0°C; Metallation; 1.75 h; 2: benzenesulfenyl chloride in diethyl ether; hexane T=-78°C; Addition; 0.5 h;
参考文献
Tetrahedron Letters, , vol. 40, # 32 p. 5943 - 5944
反应条件
1: 80 percent / 1.) BuLi; 2.) HMPA / tetrahydrofuran; hexane / 1.) 0-5 deg C; 2.) r.t., 30 min 2: 100 percent / pyridine, H2 / 5percent Pd/CaCO3 with 3.5percent lead / methanol View Scheme
参考文献
Gruiec, Regine; Noiret, Nicolas; Patin, Henri
Bulletin de la Societe Chimique de France, 1994 , vol. 131, # 6 p. 699 - 705
反应条件
1: 4-[(tetrahydro-2H-pyran-2-yl)oxy]-1-butyne With n-butyllithium in tetrahydrofuran T=0°C; 2: 1-iodo-propane in tetrahydrofuran T=0°C; 1 h;
参考文献
Satoh; Takeuchi; Nishimura; Ohta; Tobinaga
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 1 p. 18 - 22
反应条件
n-butyllithium; boron trifluoride diethyl etherate in tetrahydrofuran; hexane T=-78°C;
参考文献
Butler, Paul I.; Clarke, Trafford; Dell, Colin; Mann, John
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 11 p. 1503 - 1508
反应条件
1: n-butyllithium / tetrahydrofuran; hexane / -78 degC, allowed to warm to room temperature 2: H2 / PtO2 / methanol / 2068.6 Torr 3: hydrochloric acid / methanol / Ambient temperature View Scheme
参考文献
Deslongchamps, Pierre; Rowan, Daryl D.; Pothier, Normand; Sauve, Tilles
Canadian Journal of Chemistry, 1981 , vol. 59, p. 1105 - 1121
反应条件
(i) NaNH2, liq. NH3, (ii) /BRN= 1209224/, (iii) TsOH; Multistep reaction;
参考文献
Stoffel,W. et al.
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1964 , vol. 339, p. 182 - 193
反应条件
copper(l) iodide; diisopropylamine in benzene-d6 0.5 h; Ambient temperatureinfluence of solvents; Product distribution;
参考文献
Cai; Vasella
Helvetica Chimica Acta, 1995 , vol. 78, # 8 p. 2053 - 2064
反应条件
Yield given. Multistep reaction;
参考文献
Sargent, Melvyn V.; Wangchareontrakul, Sirichai
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1171 - 1172
反应条件
N-methyl-2,2,6,6-tetramethylpiperidine; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; trifuran-2-yl-phosphane in dimethyl sulfoxide
8 h; Ambient temperature;
参考文献
Cai; Vasella
Helvetica Chimica Acta, 1995 , vol. 78, # 8 p. 2053 - 2064
