1: ortho-fluorobromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-70°C; 0.5 h; Inert atmosphere;
2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran; hexane
0.5 h; Inert atmosphere;
参考文献
Fox Chase Chemical Diversity Center, Inc.; Advanced Neural Dynamics, Inc.; Smith, Garry Robert; Brenneman, Douglas E.; Reitz, Allen B.; Zhang, Yan; Du, Yanming
Patent: US8609849 B1, 2013 ;
Location in patent: Page/Page column 35 ;
1: ortho-iodofluorobenzene With isopropylmagnesium chloride in tetrahydrofuran
T=0°C; 0.25 h;
2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran
T=20°C;
3: With water; ammonium chloride in tetrahydrofuran
