2,6-二氯吡啶-3-甲腈合成路线 （共 12 条）
反应条件
pyridine; trifluoroacetic anhydride in dichloromethane
参考文献
Nuss, John M.; Harrison, Stephen D.; Ring, David B.; Boyce, Rustum S.; Johnson, Kirk; Pfister, Keith B.; Ramurthy, Savithri; Seely, Lynn; Wagman, Allan S.; Desai, Manjo; Levine, Barry H.
Patent: US2002/156087 A1, 2002 ;
US 20020156087 A1
反应条件
triethyl amine hydrochloride; triethylamine; trichlorophosphate T=0 - 140°C; 20 h;
参考文献
Player, Mark R.; Lu, Tianbao; Hu, Huaping; Zhu, Xizhen; Teleha, Christopher; Kreutter, Kevin
Patent: US2007/225282 A1, 2007 ;
Location in patent: Page/Page column 31-32 ;
US 20070225282 A1
反应条件
trichlorophosphate in tetrahydrofuran T=100°C; 18 h; Inert atmosphere;
参考文献
Bach, Peter; Marczynke, Michaela; Giordanetto, Fabrizio
European Journal of Organic Chemistry, 2012 , # 35 p. 6940 - 6952
反应条件
triethylamine; trichlorophosphate T=140°C; 10 h;
参考文献
Juenemann, Werner; Opgenorth, Hans-Juergen; Scheuermann, Horst
Angewandte Chemie, 1980 , vol. 92, # 5 p. 390 - 391
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / |Inert atmosphere 2: ammonia / water; 1,4-dioxane / 1.25 h / 0 °C 3: trichlorophosphate / tetrahydrofuran / 18 h / 100 °C / |Inert atmosphere View Scheme
参考文献
Bach, Peter; Marczynke, Michaela; Giordanetto, Fabrizio
European Journal of Organic Chemistry, 2012 , # 35 p. 6940 - 6952
反应条件
1: ammonia / water; 1,4-dioxane / 1.25 h / 0 °C 2: trichlorophosphate / tetrahydrofuran / 18 h / 100 °C / |Inert atmosphere View Scheme
参考文献
Bach, Peter; Marczynke, Michaela; Giordanetto, Fabrizio
European Journal of Organic Chemistry, 2012 , # 35 p. 6940 - 6952
反应条件
1: 71 percent / sodium / 1 h / Ambient temperature 2: di-isobutylaluminium hydride, methanol / toluene / 1 h / Ambient temperature View Scheme
参考文献
Dainter, Ronald S.; Jackson, Tracey; Omar, Abdirahman H. H.; Suschitzky, Hans; Wakefield, Basil J.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 283 - 287
反应条件
in methanol 1 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Dainter, Ronald S.; Jackson, Tracey; Omar, Abdirahman H. H.; Suschitzky, Hans; Wakefield, Basil J.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 283 - 287
反应条件
sodium 1 h; Ambient temperature;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 283 - 287
反应条件
in methanol 1 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Dainter, Ronald S.; Jackson, Tracey; Omar, Abdirahman H. H.; Suschitzky, Hans; Wakefield, Basil J.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 283 - 287
