4-(4-氯苯基)-4-氧代丁腈合成路线 （共 16 条）
反应条件
water; iodine; sodium hydrogencarbonate in acetone T=0°C; 2 h;
参考文献
Franz, Sarah E.; Watkins, Richard R.; Wright, Laura A.; Weaver, Blair A.; Hartage, Ramon C.; Ghiviriga, Ion; Gumina, Giuseppe; Feske, Brent D.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2013-M0268-OP, p. 2171 - 2178
反应条件
potassium cyanide in N,N-dimethyl-formamide T=80°C; 1 h;
参考文献
Miyashita, Akira; Suzuki, Yumiko; Okumura, Yoko; Iwamoto, Ken-Ichi; Higashino, Takeo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 6 - 11
反应条件
potassium cyanide in N,N-dimethyl-formamide T=80°C; 1 h;
参考文献
Miyashita; Suzuki; Okumura; Higashino
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 252 - 254
反应条件
samarium in N,N-dimethyl-formamide T=20°C; 1.5 h;
参考文献
Liu, Yongjun; Zhang, Yongmin
Journal of Chemical Research, 2004 , # 2 p. 163 - 164
反应条件
in N-methyl-acetamide; chloroform; water
参考文献
Bayer Aktiengesellschaft
Patent: US4014889 A1, 1977 ;
反应条件
1: 86 percent / DBU / dimethylformamide 2: 87 percent / KCN / dimethylformamide / 1 h / 80 °C View Scheme
参考文献
Miyashita; Suzuki; Okumura; Higashino
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 252 - 254
反应条件
1: 76 percent / diethyl ether; tetrahydrofuran / 1 h / Heating 2: 12 percent / n-Bu4NCN / tetrahydrofuran / 1.5 h / Ambient temperature 3: 86 percent / DBU / dimethylformamide 4: 87 percent / KCN / dimethylformamide / 1 h / 80 °C View Scheme
参考文献
Miyashita, Akira; Suzuki, Yumiko; Okumura, Yoko; Iwamoto, Ken-Ichi; Higashino, Takeo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 6 - 11
反应条件
1.1: n-butyllithium / tetrahydrofuran / -40 - -20 °C / |Inert atmosphere 1.2: 3 h / -78 °C / |Inert atmosphere 2.1: 18-crown-6 ether / dimethyl sulfoxide / 4 h / 100 °C / |Inert atmosphere 3.1: iodine; sodium hydrogencarbonate; water / acetone / 2 h / 0 °C View Scheme
参考文献
Franz, Sarah E.; Watkins, Richard R.; Wright, Laura A.; Weaver, Blair A.; Hartage, Ramon C.; Ghiviriga, Ion; Gumina, Giuseppe; Feske, Brent D.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2013-M0268-OP, p. 2171 - 2178
反应条件
1: 18-crown-6 ether / dimethyl sulfoxide / 4 h / 100 °C / |Inert atmosphere 2: iodine; sodium hydrogencarbonate; water / acetone / 2 h / 0 °C View Scheme
参考文献
Franz, Sarah E.; Watkins, Richard R.; Wright, Laura A.; Weaver, Blair A.; Hartage, Ramon C.; Ghiviriga, Ion; Gumina, Giuseppe; Feske, Brent D.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2013-M0268-OP, p. 2171 - 2178
反应条件
1.1: N-bromosuccinmide / 0.25 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran / -40 - -20 °C / |Inert atmosphere 2.2: 3 h / -78 °C / |Inert atmosphere 3.1: 18-crown-6 ether / dimethyl sulfoxide / 4 h / 100 °C / |Inert atmosphere 4.1: iodine; sodium hydrogencarbonate; water / acetone / 2 h / 0 °C View Scheme
参考文献
Franz, Sarah E.; Watkins, Richard R.; Wright, Laura A.; Weaver, Blair A.; Hartage, Ramon C.; Ghiviriga, Ion; Gumina, Giuseppe; Feske, Brent D.
Synthesis (Germany), 2013 , vol. 45, # 15 art. no. SS-2013-M0268-OP, p. 2171 - 2178
