1: With sodium ethanolate in ethanol
12 h;
2: With sodium hydroxide in ethanol; water
12 h;
3: With hydrogenchloride in diethyl ether; water
参考文献
Zhang, Wei; Benmohamed, Radhia; Arvanites, Anthony C.; Morimoto, Richard I.; Ferrante, Robert J.; Kirsch, Donald R.; Silverman, Richard B.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 1029 - 1045
1: With diethyl malonate in ethanol
T=25 - 60°C; Reflux;
2: With sodium hydroxide in ethanol
T=80°C; 2 h;
3: With hydrogenchloride in ethanol; water
pH=2; 1 h; Reflux;
