反应条件
1: pyrrolidine With hydrogenchloride in tetrahydrofuran; 1,4-dioxane 2: potassium thioacyanate in tetrahydrofuran; 1,4-dioxane T=20 - 100°C; 2.5 h;
参考文献
GLAXOSMITHKLINE LLC; ADJABENG, George; BAUM, Erich; BIFULCO, Neil; DAVIS-WARD, Ronda, G.; DICKERSON, Scott, Howard; DONALDSON, Kelly, Horne; HORNBERGER, Keith; PETROV, Kimberly; RHEAULT, Tara, Renae; SAMMOND, Douglas, McCord; SCHAAF, Gregory, M.; STELLWAGEN, John; UEHLING, David, Edward; WATERSON, Alex, Gregory
Patent: WO2010/104899 A1, 2010 ;
Location in patent: Page/Page column 110 ;
WO 2010/104899 A1