4-[(三氟乙酰基)氨基]苯甲酸合成路线 （共 12 条）
反应条件
in ethyl acetate 4.5 h;
参考文献
Daly; Padgett; Shamim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1520 - 1524
反应条件
trifluoroacetic anhydride in trifluoroacetic acid
参考文献
Steiner, Sandra; Li, Jim; Schoenfeld, Ryan Craig; Talamas, Francisco Xavier
Patent: US2010/158860 A1, 2010 ;
US 20100158860 A1
参考文献
Schallenberg; Calvin
Journal of the American Chemical Society, 1955 , vol. 77, p. 2779,2782
反应条件
trifluoroacetic anhydride T=0°C;
参考文献
Jones, Paul; Villeneuve, Gerald B.; Fei, Chengpei; DeMarte, Josie; Haggarty, Allison J.; Nwe, Khin Than; Martin, Deborah A.; Lebuis, Anne-Marie; Finkelstein, Joshua M.; Gour-Salin, Barbara J.; Chan, Tak Hang; Leyland-Jones, Brian R.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 16 p. 3062 - 3077
反应条件
triethylamine in tetrahydrofuran T=20°C;
参考文献
Emenike, Bright U.; Liu, Albert Tianxiang; Naveo, Elsy P.; Roberts, John D.
Journal of Organic Chemistry, 2013 , vol. 78, # 23 p. 11765 - 11771
反应条件
1: 78 percent / CH2Cl2 / 1 h / Ambient temperature 2: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 2 h, 2.) ether, hexane, -78 deg C to r.t. View Scheme
参考文献
Maunder, Peter; Finglas, Paul M.; Mallet, Anthony I.; Mellon, Fred A.; Aaqib Razzaque; Ridge, Brian; Vahteristo, Liisa; Witthoeft, Cornelia
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 10 p. 1311 - 1323
反应条件
n-butyllithium 1.) ether, hexane, -78 deg C, 2 h, 2.) ether, hexane, -78 deg C to r.t.; Yield givenMultistep reaction;
参考文献
Maunder, Peter; Finglas, Paul M.; Mallet, Anthony I.; Mellon, Fred A.; Aaqib Razzaque; Ridge, Brian; Vahteristo, Liisa; Witthoeft, Cornelia
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 10 p. 1311 - 1323
反应条件
1: 70 percent / HOBt, DCC, DIEA / tetrahydrofuran / 48 h / -5 °C 2: 61 percent / NaOH, H2O / methanol / 4 h / 23 °C View Scheme
参考文献
Maunder, Peter; Finglas, Paul M.; Mallet, Anthony I.; Mellon, Fred A.; Aaqib Razzaque; Ridge, Brian; Vahteristo, Liisa; Witthoeft, Cornelia
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 10 p. 1311 - 1323
反应条件
1: CCl4, Ph3P / acetonitrile / 0.33 h 2: acetonitrile / 0.25 h / Heating 3: aq. 1percent Na2CO3 / tetrahydrofuran; methanol / Ambient temperature View Scheme
参考文献
Jones, Paul; Villeneuve, Gerald B.; Fei, Chengpei; DeMarte, Josie; Haggarty, Allison J.; Nwe, Khin Than; Martin, Deborah A.; Lebuis, Anne-Marie; Finkelstein, Joshua M.; Gour-Salin, Barbara J.; Chan, Tak Hang; Leyland-Jones, Brian R.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 16 p. 3062 - 3077
反应条件
sodium hydroxide; diisopropyl-carbodiimide 1.) MeOH, overnight, 2.) DMF, reflux, 15 min; Yield given. Multistep reaction;
参考文献
Daly; Padgett; Shamim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1520 - 1524
