2-(4-氯苯基)-5-甲基-2H-吡唑-3-基胺合成路线 （共 4 条）
反应条件
1: 4-chloro-aniline With hydrogenchloride; sodium nitrite in water T=-2 - 0°C; 1 h; Green chemistry; 2: With ascorbic acid powder in water T=-2 - 0°C; Green chemistry; 3: 3-aminocrotononitrile in water T=45 - 90°C; Green chemistry;
参考文献
Marinozzi, Maura; Marcelli, Gloria; Carotti, Andrea; Natalini, Benedetto
RSC Advances, 2014 , vol. 4, # 14 p. 7019 - 7023
反应条件
1: With triethylamine in ethanol Heating; 2: With sodium acetate; acetic acid T=90°C;
参考文献
Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Yamamoto, Susumu; Takeda, Hiroshi; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 9 p. 1098 - 1104
反应条件
in ethanol; acetic acid 3 h; Heating;
参考文献
Simay, A.; Takacs, K.; Horvath, K.; Dvortsak, P.
Acta Chimica Academiae Scientiarum Hungaricae, 1980 , vol. 105, p. 127 - 140
反应条件
hydrogenchloride; EtO-NO in ethanol
T=0°C;
参考文献
Giori; Mazzotta; Vertuani; Guarneri; Pancaldi; Brunelli
Farmaco, Edizione Scientifica, 1981 , vol. 36, # 12 p. 1019 - 1028
