1.1: Li / tetrahydrofuran / 2 h / 25 °C 2.1: tetrahydrofuran / 50 °C 2.2: tetrahydrofuran / 16 h / 60 °C View Scheme

1: lithium 3,4-dimethyl-1-phospholide; acetyl chloride in tetrahydrofuran T=50°C; 2: 3-(bromo)propionic acid ethyl ester in tetrahydrofuran T=60°C; 16 h;

T=20°C; 1 h;