2-(噻吩-2-基)乙基对甲苯磺酸酯合成路线 （共 14 条）
反应条件
triethylamine in toluene T=5 - 30°C; 20.8333 h; Product distribution / selectivity;
参考文献
Sajja, Eswaraiah; Anumula, Raghupathi Reddy; Gilla, Goverdhan; Madivada, Lokeswara Rao
Patent: US2007/225320 A1, 2007 ;
Location in patent: Page/Page column 5 ;
反应条件
potassium hydrogensulfate in pyridine
参考文献
G. D. Searle and Co.
Patent: US4822775 A1, 1989 ;
反应条件
triethylamine in di-isopropyl ether T=20°C; 50 h;
参考文献
Ferraboschi, Patrizia; Mieri, Maria De; Galimberti, Fiorella
Tetrahedron Asymmetry, 2010 , vol. 21, # 17 p. 2136 - 2141
反应条件
sodium sulfite in anhydrous xylene 60 h; Reflux;
参考文献
SHAN DONG LUYE PHARMACEUTICAL CO., LTD.; Meng, Qingguo; Yang, Mina; Wang, Tao; Wang, Qilin; Li, Jun; Ruan, Zheng
Patent: US2014/121380 A1, 2014 ;
Location in patent: Paragraph 0059 ;
反应条件
sodium carbonate in anhydrous xylene T=140°C; 24 h;
参考文献
Organic Letters, , vol. 12, # 23 p. 5418 - 5421
反应条件
1: (S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide With sodium carbonate in o-xylene; water T=70 - 80°C; 2: [2-(thien-2-yl)ethyl] 4-methylbenzenesulfonate With sodium carbonate in o-xylene Reflux;
参考文献
US2013/102794 A1, ;
Paragraph 0257-0260 ;
反应条件
in 2-methylpropyl acetate T=110°C; 10 h; Product distribution / selectivity;
参考文献
WO2009/53697 A1, ;
Page/Page column 14; 15 ;
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 8.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/87779 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1.1: sodium hydrogencarbonate / toluene / 25 - 30 °C 1.2: 85 - 90 °C 2.1: water / 25 - 35 °C 2.2: pH 7 - 8 View Scheme
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LTD; RAO, Jagadeeshwar; NANDAM, Harikrishna; REDAMALLA, Anjireddy; REGURI, Buchi, Reddy
Patent: WO2011/12961 A1, 2011 ;
反应条件
1: (S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide With sodium carbonate in o-xylene; water T=70 - 80°C; 2: [2-(thien-2-yl)ethyl] 4-methylbenzenesulfonate With sodium carbonate in o-xylene Reflux; 3: With hydrogenchloride in o-xylene; water; isopropyl alcohol; toluene T=15 - 55°C;
参考文献
UCB PHARMA GMBH; ATES, Celal; SCHULE, Arnaud; PALACIO, Magali; DEUTSCH, Paul; VASSELIN, David; CARLY, Nicolas; PHADTARE, Ganesh; YERANDE, Swapnil; DELATINNE, Jean-Pierre; ESCUDERO HERNANDEZ, Maria Luisa; PINILLA, Veronique
Patent: WO2011/161255 A2, 2011 ;
Location in patent: Page/Page column 36-37 ;
