1-(4-羟基-1-哌啶)-乙酮合成路线 (共 12 条)
反应条件
triethylamine in dichloromethane T=-78 - 20°C;
参考文献
Briner, Karin; Doecke, Christopher William; Mancuso, Vincent; Martinelli, Michael John; Richardson, Timothy Ivo; Rothhaar, Roger Ryan; Shi, Qing; Xie, Chaoyu
Patent: US2004/82590 A1, 2004 ;
Location in patent: Page/Page column 40 ;
US 20040082590 A1
反应条件
in methanol 72 h; Ambient temperature;
参考文献
Kucznierz, Ralf; Grams, Frank; Leinert, Herbert; Marzenell, Klaus; Engh, Richard A.; Von der Saal, Wolfgang
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4983 - 4994
反应条件
sodium tetrahydroborate in ethyl acetate; isopropyl alcohol
参考文献
American Home Products Corporation
Patent: US5202346 A1, 1993 ;
参考文献
Atkinson, Robert S.; Barker, Emma; Sutcliffe, Michael J.
Chemical Communications, 1996 , # 9 p. 1051 - 1052
反应条件
1: Raney nickel; ethanol / 50 °C / 36775.4 Torr / Hydrogenation 2: cyclohexanol View Scheme
参考文献
Bowden; Green
Journal of the Chemical Society, 1952 , p. 1164,1166
参考文献
Bowden; Green
Journal of the Chemical Society, 1952 , p. 1164,1166
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 4 h; Heating;
参考文献
Kuroda; Takamura; Tenda; Itani; Tomishima; Akahane; Sakane
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 8 p. 988 - 998
反应条件
1: NaH / dimethylformamide 2: NaOH / ethanol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 243 - 250
反应条件
1: T=130°C; 5 h; Large scale; 2: With hydrogenchloride in water T=80°C; 15 h; Large scale;
参考文献
EVERLIGHT USA, INC.; CHEN, Tsung-Ting; YANG, Hao-Cheng; CHOU, Tsai-Yung; YAO, Chi-Hsiang
Patent: US2014/46068 A1, 2014 ;
Location in patent: Paragraph 0039; 0042; 0043; 0044; 0045; 0046; 0047 ;
反应条件
1.1: 5 h / 130 °C / |Large scale 1.2: 15 h / 80 °C / |Large scale 2.1: sodium iodide; potassium carbonate / acetonitrile / 15 h / 80 °C / |Large scale 3.1: acetic acid / water 4.1: sodium hydroxide / ethanol / 15 h / 20 °C 5.1: acetonitrile / 15 h / 20 °C View Scheme
参考文献
EVERLIGHT USA, INC.; CHEN, Tsung-Ting; YANG, Hao-Cheng; CHOU, Tsai-Yung; YAO, Chi-Hsiang
Patent: US2014/46068 A1, 2014 ;