alpha-甲基-2-菲乙酸合成路线 （共 8 条）
反应条件
sulfuric acid in water; acetic acid
2 h; Heating;
参考文献
Fernandez; Gonzalez; Gomez; Lopez; Medina
Archiv der Pharmazie, 1990 , vol. 323, # 4 p. 239 - 242
反应条件
1: 99 percent Chromat. / NaBH4 / tetrahydrofuran; ethanol / 12 h / Ambient temperature
2: 95 percent / SOCl2 / benzene / 4 h / Heating
3: 38 percent / dimethylsulfoxide / 7 h / 70 - 75 °C
4: 67 percent / H2SO4 / acetic acid; H2O / 2 h / Heating
View Scheme
参考文献
Fernandez; Gonzalez; Gomez; Lopez; Medina
Archiv der Pharmazie, 1990 , vol. 323, # 4 p. 239 - 242
反应条件
chromium(VI) oxide; sulfuric acid in acetone
参考文献
Roszkowski; Schuler; Nelson
Journal of medicinal chemistry, 1972 , vol. 15, # 12 p. 1336 - 1338
反应条件
1: 95 percent / SOCl2 / benzene / 4 h / Heating
2: 38 percent / dimethylsulfoxide / 7 h / 70 - 75 °C
3: 67 percent / H2SO4 / acetic acid; H2O / 2 h / Heating
View Scheme
参考文献
Fernandez; Gonzalez; Gomez; Lopez; Medina
Archiv der Pharmazie, 1990 , vol. 323, # 4 p. 239 - 242
反应条件
1: 38 percent / dimethylsulfoxide / 7 h / 70 - 75 °C
2: 67 percent / H2SO4 / acetic acid; H2O / 2 h / Heating
View Scheme
参考文献
Fernandez; Gonzalez; Gomez; Lopez; Medina
Archiv der Pharmazie, 1990 , vol. 323, # 4 p. 239 - 242
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
8 h; Heating; Yields of byproduct given;
参考文献
Balo; Fernandez; Gomez; Gonzalez; Lopez
Archiv der Pharmazie, 1991 , vol. 324, # 12 p. 967 - 969
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
1) CH2Cl2, room temperature, 3 h, 2) reflux, 8 h; Yield given. Multistep reaction;
参考文献
Balo; Fernandez; Gomez; Gonzalez; Lopez
Archiv der Pharmazie, 1991 , vol. 324, # 12 p. 967 - 969
反应条件
(i) CH2N2, (ii) LiAlH4, Et2O; Multistep reaction;
参考文献
Roszkowski; Schuler; Nelson
Journal of medicinal chemistry, 1972 , vol. 15, # 12 p. 1336 - 1338
