1: 1.) KOH / 1.) H2O, reflux, 2.) H2O, reflux, 30 min 2: 1.) 1 h, 0 deg C, 2.) 2 h, RT 3: acetic acid / 1.) 30 min, 2.) 2 h 4: 82 percent / H2O / 1.) reflux, 15 min, 2.) reflux, 10 h 5: 76 percent / aq. diethylamine / Heating 6: 49 percent / dimethylformamide View Scheme

1: acetic acid / 1.) 30 min, 2.) 2 h 2: 82 percent / H2O / 1.) reflux, 15 min, 2.) reflux, 10 h 3: 76 percent / aq. diethylamine / Heating 4: 49 percent / dimethylformamide View Scheme

in N,N-dimethyl-formamide

1: 82 percent / H2O / 1.) reflux, 15 min, 2.) reflux, 10 h 2: 76 percent / aq. diethylamine / Heating 3: 49 percent / dimethylformamide View Scheme

1: 76 percent / aq. diethylamine / Heating 2: 49 percent / dimethylformamide View Scheme