4-甲基-1-苯基-3-戊酮合成路线 （共 37 条）
反应条件
Cy2NiBu; SiCl3OTf in dichloromethane
T=-40°C; 0.5 h; Inert atmosphere;
参考文献
Kotani, Shunsuke; Osakama, Kazuki; Sugiura, Masaharu; Nakajima, Makoto
Organic Letters, 2011 , vol. 13, # 15 p. 3968 - 3971
反应条件
potassium hydroxide; dodec-1-ene; tris(triphenylphosphine)ruthenium(II) chloride in 1,4-dioxane
T=80°C; 20 h;
参考文献
Cho, Chan Sik; Kim, Bok Tae; Kim, Tae-Jeong; Chul Shim, Sang
Tetrahedron Letters, 2002 , vol. 43, # 44 p. 7987 - 7989
反应条件
1: isopropyllithium With copper (I) cyanide in diethyl ether; pentane
T=0°C; 0.0833333 h; Inert atmosphere;
2: 3-phenylpropionic acid in diethyl ether; pentane
T=0 - 20°C; 15 h; Inert atmosphere;
参考文献
Genna, Douglas T.; Posner, Gary H.
Organic Letters, 2011 , vol. 13, # 19 p. 5358 - 5361
反应条件
Grignard reagent; N,N-diphenyl-p-methoxyphenylchloromethyleniminium chloride; copper(l) iodide in tetrahydrofuran; dichloromethane
1) -30 deg C, 1 h, 2) 0 deg C, 1 h;
参考文献
Fujisawa, Tamotsu; Mori, Toshiki; Sato, Toshio
Tetrahedron Letters, 1982 , vol. 23, # 48 p. 5059 - 5062
反应条件
oxygen; palladium diacetate; acetic acid; copper(l) chloride in dimethyl sulfoxide
T=50°C; P=760.051 Torr; 20 h; regioselective reaction;
参考文献
Chen, Mao; Wang, Jie; Chai, Ziyi; You, Cai; Lei, Aiwen
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 2-3 p. 341 - 346
反应条件
tetrabutylammomium bromide; sodium formate; sodium hydrogencarbonate; Pd-benzothiazole carbene
T=130°C; 4 h;
参考文献
Calo, Vincenzo; Nacci, Angelo; Lopez, Luigi; Napola, Annalisa
Tetrahedron Letters, 2001 , vol. 42, # 28 p. 4701 - 4703
反应条件
potassium hydroxide; tris(triphenylphosphine)ruthenium(II) chloride in 1,4-dioxane
T=80°C; 40 h;
参考文献
Cho, Chan Sik; Shim, Sang Chul
Journal of Organometallic Chemistry, 2006 , vol. 691, # 20 p. 4329 - 4332
反应条件
copper(l) iodide in tetrahydrofuran
T=-78 - 20°C; 18 h;
参考文献
Chan, Louis K. M.; Poole, Darren L.; Shen, Di; Healy, Mark P.; Donohoe, Timothy J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 3 p. 761 - 765
Angew. Chem., 2014 , vol. 126, # 3 p. 908
反应条件
in tetrahydrofuran
T=-20 - 18°C; Grignard reaction; 18.5 h;
参考文献
Mattson, Matthew N.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6071 - 6074
反应条件
hydrogenchloride in tetrahydrofuran; diethyl ether
T=20°C; 10 h; Yield given;
参考文献
Katritzky, Alan R.; Zhang, Guifen; Jiang, Jinlong
Journal of Organic Chemistry, 1995 , vol. 60, # 23 p. 7605 - 7611
