4-甲基-1-苯基-3-戊酮合成路线 （共 37 条）
反应条件
1: 78 percent / MCPBA / CH2Cl2 / Ambient temperature
2: H-beta / benzene; various solvent(s) / 24 h / 80 °C
View Scheme
参考文献
Elings, Jacob A.; Downing, Roger S.; Sheldon, Roger A.
European Journal of Organic Chemistry, 1999 , # 4 p. 837 - 846
反应条件
n-butyllithium in diethyl ether
0.25 h;
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Onda, Ken-ichi; Kitoh, Yasushi; Yamakawa, Koji
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 10 p. 2800 - 2806
反应条件
H-beta in benzene
T=80°C; 24 h; Yield givenYields of byproduct given;
参考文献
Elings, Jacob A.; Downing, Roger S.; Sheldon, Roger A.
European Journal of Organic Chemistry, 1999 , # 4 p. 837 - 846
反应条件
H-beta in benzene
T=80°C; 0.0833333 h; Yield givenFurther byproducts given. Yields of byproduct given;
参考文献
Elings, Jacob A.; Downing, Roger S.; Sheldon, Roger A.
European Journal of Organic Chemistry, 1999 , # 4 p. 837 - 846
反应条件
1: 99 percent / methanesulfonic acid / CH2Cl2 / 4.5 h / -40 - 0 °C
2: 82 percent / tetrahydrofuran / 18.5 h / -20 - 18 °C
View Scheme
参考文献
Mattson, Matthew N.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6071 - 6074
反应条件
1: tetrahydrofuran; diethyl ether / 1.) -78 to 20 deg C, 2.) reflux, 10 h
2: 2 N aq. HCl / tetrahydrofuran; diethyl ether / 10 h / 20 °C
View Scheme
参考文献
Katritzky, Alan R.; Zhang, Guifen; Jiang, Jinlong
Journal of Organic Chemistry, 1995 , vol. 60, # 23 p. 7605 - 7611
反应条件
1: 3-phenylpropionic acid With 1,2-dihydrofuran; methanesulfonic acid in dichloromethane
T=-5°C; 4 h;
2: isopropylmagnesium chloride in tetrahydrofuran
T=20°C; 16 h;
参考文献
Sumitomo Pharmaceuticals Company
Patent: US6369110 B1, 2002 ;
Location in patent: Page column 66-67 ;
反应条件
1: 93 percent / 1.) n-BuLi, diisopropylamine / tetrahydrofuran / 0.42 h / -65 °C
2: 47 percent / 1.) LDA; 2.) 3 eq. t-BuLi / tetrahydrofuran / -70 °C
3: 66 percent / 1.) n-BuLi, diisopropylamine / tetrahydrofuran / 0.42 h / -65 °C
4: 41 percent / 1.) 1.5 eq. KH; 2.) 3 eq. t-BuLi / tetrahydrofuran / 1.) 0 deg C, 20 min; 2.) -70 deg C, 10 min
View Scheme
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Gengyo, Kaoru; Takada, Sae; Asakawa, Naoyuki; et al.
Tetrahedron, 1994 , vol. 50, # 41 p. 11839 - 11852
反应条件
1: 66 percent / 1.) n-BuLi, diisopropylamine / tetrahydrofuran / 0.42 h / -65 °C
2: 41 percent / 1.) 1.5 eq. KH; 2.) 3 eq. t-BuLi / tetrahydrofuran / 1.) 0 deg C, 20 min; 2.) -70 deg C, 10 min
View Scheme
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Gengyo, Kaoru; Takada, Sae; Asakawa, Naoyuki; et al.
Tetrahedron, 1994 , vol. 50, # 41 p. 11839 - 11852
反应条件
1: 47 percent / 1.) LDA; 2.) 3 eq. t-BuLi / tetrahydrofuran / -70 °C
2: 66 percent / 1.) n-BuLi, diisopropylamine / tetrahydrofuran / 0.42 h / -65 °C
3: 41 percent / 1.) 1.5 eq. KH; 2.) 3 eq. t-BuLi / tetrahydrofuran / 1.) 0 deg C, 20 min; 2.) -70 deg C, 10 min
View Scheme
参考文献
Satoh, Tsuyoshi; Itoh, Norifumi; Gengyo, Kaoru; Takada, Sae; Asakawa, Naoyuki; et al.
Tetrahedron, 1994 , vol. 50, # 41 p. 11839 - 11852
