2-羟基-6-苄氧基苯乙酮合成路线 （共 14 条）
反应条件
1: 1.) lithium diisopropylamide, 2.) hexamethylphosphoric triamide / 1.) THF, -78 deg C, 2 h, 2.) -78 deg C, 1 h, then -15 deg C, 30 min
2: 88 percent / p-toluenesulfonic acid / benzene / 1 h / Heating
3: 88 percent / hydrogen / 10 percent Pd-C / acetone / 6 h / 2574.3 Torr / Ambient temperature
4: 96 percent / boron tribromide / CH2Cl2 / 0.33 h / Ambient temperature
View Scheme
参考文献
Tsuda; Hosoi; Goto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 1 p. 18 - 22
反应条件
1: 1.) lithium diisopropylamide, 2.) hexamethylphosphoric triamide / 1.) THF, -78 deg C, 2 h, 2.) -78 deg C, 1 h, then -15 deg C, 30 min
2: 91 percent / p-toluenesulfonic acid / benzene / 1 h / Heating
3: 88 percent / hydrogen / 10 percent Pd-C / acetone / 6 h / 2574.3 Torr / Ambient temperature
4: 97 percent / boron tribromide / CH2Cl2 / 0.17 h / Ambient temperature
View Scheme
参考文献
Tsuda; Hosoi; Goto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 1 p. 18 - 22
反应条件
sodium hydride in tetrahydrofuran
T=20°C; 48 h;
参考文献
Brunskole, Mojca; Stefane, Bogdan; Zorko, Karmen; Anderluh, Marko; Stojan, Jure; Lanisnik Rizner, Tea; Gobec, Stanislav
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5881 - 5889
反应条件
sodium in diphenylether; xylene
T=160°C; 1 h;
参考文献
Di Braccio, Mario; Grossi, Giancarlo; Roma, Giorgio; Signorello, Maria Grazia; Leoncini, Giuliana
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 5 p. 397 - 409
