2-(5-氯吡啶-2-基)丙烷-2-醇合成路线 （共 3 条）
反应条件
1: in tetrahydrofuran
T=5 - 30°C;
2: With hydrogenchloride in tetrahydrofuran; methanol; water; ethyl acetate
T=30°C; pH=4;
3: With sodium hydroxide in water
pH=8;
参考文献
Albaneze-Walker, Jennifer; Ceglia, Scott; Murry, Jerry Anthony; Soheili, Arash
Patent: US2004/102472 A1, 2004 ;
Location in patent: Page 50 ;
US 20040102472 A1
反应条件
sodium chloride in tetrahydrofuran
T=20 - 25°C;
参考文献
Albaneze-Walker, Jennifer; Murry, Jerry A.; Soheili, Arash; Ceglia, Scott; Springfield, Shawn A.; Bazaral, Charles; Dormer, Peter G.; Hughes, David L.
Tetrahedron, 2005 , vol. 61, # 26 p. 6330 - 6336
反应条件
1: triethylamine; dppf / palladium(II) acetate / 11 h / 100 °C / 2585.74 Torr
2: 89 percent / sodium chloride / tetrahydrofuran / 20 - 25 °C
View Scheme
参考文献
Albaneze-Walker, Jennifer; Murry, Jerry A.; Soheili, Arash; Ceglia, Scott; Springfield, Shawn A.; Bazaral, Charles; Dormer, Peter G.; Hughes, David L.
Tetrahedron, 2005 , vol. 61, # 26 p. 6330 - 6336
