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乙二醇
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63148-62-9
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碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2-溴-6-甲氧基吡啶
合成路线
（共 50 条）
40473-07-2
2-溴-6-甲氧基吡啶
→
反应条件
762228-49-9
[2-(1-羟基-6-氧代-1,6-二氢-2-吡啶基)乙基]膦酸
反应条件
1: t-Bu4NOAc; potassium chloride; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 90 °C 2: palladium 10 on activated carbon; hydrogen / methanol / 20 °C 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C 4: trimethylsilyl bromide; water / dichloromethane / 20 °C View Scheme
参考文献
Andaloussi, Mounir; Lindh, Martin; Bjoerkelid, Christofer; Suresh, Surisetti; Wieckowska, Anna; Iyer, Harini; Karlen, Anders; Larhed, Mats
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5403 - 5407
40473-07-2
2-溴-6-甲氧基吡啶
→
反应条件
909720-21-4
2,3-二溴-6-甲氧基吡啶
反应条件
N-bromosuccinmide in acetonitrile T=90°C;
参考文献
Allcock, Robert W.; Blakli, Haakon; Jiang, Zhong; Johnston, Karen A.; Morgan, Keith M.; Rosair, Georgina M.; Iwase, Kazuhiko; Kohno, Yasushi; Adams, David R.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3307 - 3312
40473-07-2
2-溴-6-甲氧基吡啶
→
反应条件
89324-17-4
2-氰基-6-羟基吡啶
反应条件
1.1: dimethylformamide / 48 h / 150 °C 1.2: 62 percent / FeCl3*6H2O; aq. HCl / dimethylformamide / 0.42 h / 80 °C 2.1: 82 percent / TMSCl; NaI / acetonitrile / 6 h / 80 °C View Scheme
参考文献
Bowman; Bridge; Cloonan; Leach
Synlett, 2001 , # 6 p. 765 - 768
40473-07-2
2-溴-6-甲氧基吡啶
→
反应条件
623942-84-7
3-溴-2-羟甲基-6-甲氧基吡啶
反应条件
1.1: n-hexyl lithium / tetrahydrofuran / -65 - -60 °C 1.2: -60 °C 2.1: bromine / dichloromethane / -20 - 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; THOMPSON, Christopher, F.; SWEIS, Ramzi, F.
Patent: WO2011/28395 A1, 2011 ;
40473-07-2
2-溴-6-甲氧基吡啶
+
17997-47-6
2-三正丁基甲锡烷基吡啶
→
反应条件
54015-96-2
反应条件
1: With lithium chloride; bis-triphenylphosphine-palladium(II) chloride in toluene 18 h; Heating; 2: With NAF in water; toluene T=20°C; 0.5 h;
参考文献
Tomon, Takashi; Koizumi, Take-Aki; Tanaka, Koji
European Journal of Inorganic Chemistry, 2005 , # 2 p. 285 - 293
40473-07-2
2-溴-6-甲氧基吡啶
+
13737-04-7
→
反应条件
54015-96-2
反应条件
potassium fluoride; copper(l) iodide; palladium diacetate; di-(1-adamantyl)-n-butylphosphine in N,N-dimethyl-formamide T=90°C; Hiyama coupling; 12 h; Inert atmosphere;
参考文献
Blakemore, David C.; Marples, Louise A.
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4192 - 4195
40473-07-2
2-溴-6-甲氧基吡啶
→
反应条件
54015-96-2
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; 24 h; Inert atmosphere;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Tetrahedron, 2010 , vol. 66, # 17 p. 3135 - 3146
109-04-6
邻溴吡啶
+
40473-07-2
2-溴-6-甲氧基吡啶
→
反应条件
54015-96-2
反应条件
NiII chloride hexahydrate; iodine; acetic acid; lithium chloride; zinc in N,N-dimethyl-formamide T=50 - 70°C; 6 h;
参考文献
Liao, Lian-Yan; Kong, Xing-Rui; Duan, Xin-Fang
Journal of Organic Chemistry, 2014 , vol. 79, # 2 p. 777 - 782
40473-07-2
2-溴-6-甲氧基吡啶
+
882521-96-2
→
反应条件
54015-96-2
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); potassium carbonate in tetrahydrofuran Suzuki-Miyaura cross-coupling; 24 h; RefluxInert atmosphere;
参考文献
Guetz, Christoph; Luetzen, Arne
Synthesis, 2010 , # 1 p. 85 - 90
40473-07-2
2-溴-6-甲氧基吡啶
→
反应条件
405103-68-6
反应条件
1: N,N-dimethyl-formamide / 16 h / 20 - 100 °C 2: thionyl chloride / 16 h / 70 °C 3: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C 4: thionyl chloride / monofluorodichloromethane / 2 h / 0 - 50 °C / Inert atmosphere View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
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