4-苯基哌啶-4-甲腈合成路线

参考文献

AUSPEX PHARMACEUTICALS, INC.
Patent: US2011/160244 A1, 2011 ;
Location in patent: Page/Page column 10 ;
US 20110160244 A1

50-00-0甲醛+

40481-13-84-苯基哌啶-4-甲腈+

149-73-5原甲酸三甲酯

3627-62-14-氰基-1-甲基-4-苯基哌啶

参考文献

BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2008/124757 A1, 2008 ;
Location in patent: Page/Page column 53 ;
WO 2008/124757 A1

40481-13-84-苯基哌啶-4-甲腈+

74-88-4甲基碘

3627-62-14-氰基-1-甲基-4-苯基哌啶

参考文献

Mercer, Susan L.; Cunningham, Christopher W.; Eddington, Natalie D.; Coop, Andrew
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 12 p. 3638 - 3640

40481-13-84-苯基哌啶-4-甲腈

3627-62-14-氰基-1-甲基-4-苯基哌啶

参考文献

Mercer, Susan L.; Hassan, Hazem E.; Cunningham, Christopher W.; Eddington, Natalie D.; Coop, Andrew
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1160 - 1162

51304-58-64-氰基-4-苯基哌嗪

40481-13-84-苯基哌啶-4-甲腈

参考文献

NEUROCHEM (INTERNATIONAL) LIMITED
Patent: WO2004/113275 A2, 2004 ;
Location in patent: Page 170; 171 ;

56243-25-51-苄基-4-氰基-4-苯基哌啶盐酸盐

40481-13-84-苯基哌啶-4-甲腈

参考文献

Tang, Haifeng; Yan, Yan; Feng, Zhe; De Jesus, Reynalda K.; Yang, Lihu; Levorse, Dorothy A.; Owens, Karen A.; Akiyama, Taro E.; Bergeron, Raynald; Castriota, Gino A.; Doebber, Thomas W.; Ellsworth, Kenneth P.; Lassman, Michael E.; Li, Cai; Wu, Margaret S.; Zhang, Bei B.; Chapman, Kevin T.; Mills, Sander G.; Berger, Joel P.; Pasternak, Alexander
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 20 p. 6088 - 6092

140-29-4氰化苄+

334-22-5二(2-氯乙基)氯化铵

40481-13-84-苯基哌啶-4-甲腈

参考文献

Kwartler; Lucas
Journal of the American Chemical Society, 1947 , vol. 69, p. 2582,2585

158144-79-74-氰基-4-苯基哌啶-1-羧酸叔丁酯

40481-13-84-苯基哌啶-4-甲腈

参考文献

Patane, Michael A.; DiPardo, Robert M.; Newton, Randall C.; Price, RoseAnn P.; Broten, Theodore P.; Chang, Raymond S.L.; Ransom, Richard W.; Di Salvo, Jerry; Nagarathnam, Dhanapalan; Forray, Carlos; Gluchowski, Charles; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1621 - 1624

140-29-4氰化苄

40481-13-84-苯基哌啶-4-甲腈

参考文献

Patane, Michael A.; DiPardo, Robert M.; Newton, Randall C.; Price, RoseAnn P.; Broten, Theodore P.; Chang, Raymond S.L.; Ransom, Richard W.; Di Salvo, Jerry; Nagarathnam, Dhanapalan; Forray, Carlos; Gluchowski, Charles; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1621 - 1624

40481-13-84-苯基哌啶-4-甲腈

84176-77-2(1-苄基-4-苯基哌啶-4-基)甲胺

参考文献

Rehse; Werner
Archiv der Pharmazie, 1986 , vol. 319, # 6 p. 505 - 515