4-[(2-氟苄)氧基]苯甲酸合成路线 （共 5 条）
反应条件
1: With water; potassium hydroxide in tetrahydrofuran; methanol
T=20 - 25°C; 36 h;
2: With hydrogenchloride in tetrahydrofuran; methanol; water
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; ZAJAC, Matthew, Allen
Patent: WO2011/29762 A1, 2011 ;
Location in patent: Page/Page column 14-15 ;
WO 2011/029762 A1
反应条件
1.1: potassium carbonate / acetonitrile / 0.08 h
1.2: 2 h / 50 - 55 °C
2.1: potassium hydroxide; water / tetrahydrofuran; methanol / 36 h / 20 - 25 °C
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; ZAJAC, Matthew, Allen
Patent: WO2011/29762 A1, 2011 ;
WO 2011/029762 A1
反应条件
1.1: potassium carbonate / acetonitrile / 0.08 h
1.2: 2 h / 50 - 55 °C
2.1: potassium hydroxide; water / tetrahydrofuran; methanol / 36 h / 20 - 25 °C
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; ZAJAC, Matthew, Allen
Patent: WO2011/29762 A1, 2011 ;
WO 2011/029762 A1
参考文献
Jones
Journal of the Chemical Society, 1935 , p. 1835
Journal of the Chemical Society, 1938 , p. 1414
反应条件
1.1: thionyl chloride / 3 h / 65 °C / Inert atmosphere
1.2: 0 - 25 °C
2.1: tetrahydrofuran / -78 - 25 °C
3.1: 2,6-di-tert-butyl-4-methyl-phenol / [Cu(I)(CH3CN)4]PF6; (S,S)-i-Pr-FOXAP / tetrahydrofuran / -78 °C / Inert atmosphere
3.2: -78 °C
4.1: hydrogen; acetic acid / 5 Pd(II)/C(eggshell) / ethanol / 2 h / 15 - 20 °C / 2585.81 Torr / Inert atmosphere
4.2: 24 h / 15 - 20 °C
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; ZAJAC, Matthew, Allen
Patent: WO2011/29762 A1, 2011 ;
WO 2011/029762 A1
