4-氟苯乙酸合成路线

参考文献

Ellingboe, John W.; Lombardo, Louis J.; Alessi, Thomas R.; Nguyen, Thomas T.; Guzzo, Frieda; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2485 - 2493

405-50-54-氟苯乙酸

34837-84-84-氟苯基乙酸甲酯

参考文献

ABBOTT LABORATORIES
Patent: WO2005/19191 A2, 2005 ;
Location in patent: Page/Page column 147 ;
WO 2005/019191 A2

67-56-1甲醇+

405-50-54-氟苯乙酸

34837-84-84-氟苯基乙酸甲酯

参考文献

Park, William K.C.; Kennedy, Robert M.; Larsen, Scott D.; Miller, Steve; Roth, Bruce D.; Song, Yuntao; Steinbaugh, Bruce A.; Sun, Kevin; Tait, Bradley D.; Kowala, Mark C.; Trivedi, Bharat K.; Auerbach, Bruce; Askew, Valerie; Dillon, Lisa; Hanselman, Jeffrey C.; Lin, Zhiwu; Lu, Gina H.; Robertson, Andrew; Sekerke, Catherine
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1151 - 1156

18107-18-1三甲基硅烷化重氮甲烷+

405-50-54-氟苯乙酸

34837-84-84-氟苯基乙酸甲酯

参考文献

Lynch, Christopher L.; Willoughby, Christopher A.; Hale, Jeffrey J.; Holson, Edward J.; Budhu, Richard J.; Gentry, Amy L.; Rosauer, Keith G.; Caldwell, Charles G.; Chen, Ping; Mills, Sander G.; MacCoss, Malcolm; Berk, Scott; Chen, Liya; Chapman, Kevin T.; Malkowitz, Lorraine; Springer, Martin S.; Gould, Sandra L.; DeMartino, Julie A.; Siciliano, Salvatore J.; Cascieri, Margaret A.; Carella, Anthony; Carver, Gwen; Holmes, Karen; Schleif, William A.; Danzeisen, Renee; Hazuda, Daria; Kessler, Joseph; Lineberger, Janet; Miller, Michael; Emini, Emilio A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 119 - 123

405-50-54-氟苯乙酸

142272-54-6

参考文献

Yang; Hay
Synthesis, 1992 , # 5 p. 467 - 472

405-50-54-氟苯乙酸

459-04-1对氟苯乙酰氯

参考文献

Chatterjee, Arnab K.; Liu, Hong; Tully, David C.; Guo, Jianhua; Epple, Robert; Russo, Ross; Williams, Jennifer; Roberts, Michael; Tuntland, Tove; Chang, Jonathan; Gordon, Perry; Hollenbeck, Thomas; Tumanut, Christine; Li, Jun; Harris, Jennifer L.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2899 - 2903

79-37-8草酰氯+

405-50-54-氟苯乙酸

459-04-1对氟苯乙酰氯

参考文献

Pineiro, Jose Luis Castro; Churcher, Ian; Guiblin, Alexander Richard; Harrison, Timothy; Kerrard, Sonia; Madin, Andrew; Nadin, Alan John; Owens, Andrew Pate; Sparey, Timothy Jason; Teall, Martin Richard; Williams, Susannah
Patent: US2004/82572 A1, 2004 ;

405-50-54-氟苯乙酸

456-22-4对氟苯甲酸+

459-57-4对氟苯甲醛

参考文献

Farhadi, Saeid; Zabardasti, Abedien; Rahmati, Mohammad Hosien
Journal of Chemical Research, 2011 , vol. 35, # 3 p. 157 - 160

917-54-4甲基锂+

405-50-54-氟苯乙酸

459-03-04-氟苯基丙酮

参考文献

Werbel; Cook; Elslager; Hung; Johnson; Kesten; McNamara; Ortwine; Worth
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 924 - 939

405-50-54-氟苯乙酸

459-57-4对氟苯甲醛

参考文献

Farhadi; Ansari
Journal of the Iranian Chemical Society, 2011 , vol. 8, # 2 p. 470 - 476