sodium azide; chloroform; sulfuric acid

1: 3-(tetrahydro-2H-pyran-4-yl)propanoic acid With thionyl chloride 1 h; Heating / reflux; 2: 1,1-dimethylethylmagnesium chloride With copper(l) chloride in tetrahydrofuran T=0 - 20°C; 3: With water; ammonium chloride in tetrahydrofuran T=0°C;

hydrogen bromide T=100°C; Behandeln des Reaktionsprodukts mit Diazomethan, Erhitzen des erhaltenen Esters mit NH3 in Methanol auf 130grad und Behandeln des Reaktionsgemisches mit Ba(OH)2 und Wasserdampf;

formic acid; triethylamine T=100°C; Knoevenagel condensation; 5 h;

1.1: magnesium chloride / tetrahydrofuran / 2.5 h / 10 - 50 °C / Industry scale 1.2: 18.5 h / 30 - 34 °C / Industry scale 2.1: sodium tetrahydroborate / 1.42 h / 10 - 39 °C 2.2: 0 - 5 °C 3.1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 3 h / 20 - 35 °C 4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 24 h / 35 - 50 °C 5.1: hydrogen / palladium(II) oxide hydrate / ethanol / 5 h / 30 °C / 155.15 Torr 6.1: sodium hydroxide; water / ethanol / 16 h 6.2: 1 h / 0 - 5 °C / pH 1 View Scheme

1.1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 3 h / 20 - 35 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 24 h / 35 - 50 °C 3.1: hydrogen / palladium(II) oxide hydrate / ethanol / 5 h / 30 °C / 155.15 Torr 4.1: sodium hydroxide; water / ethanol / 16 h 4.2: 1 h / 0 - 5 °C / pH 1 View Scheme

1.1: hydrogen / palladium(II) oxide hydrate / ethanol / 5 h / 30 °C / 155.15 Torr 2.1: sodium hydroxide; water / ethanol / 16 h 2.2: 1 h / 0 - 5 °C / pH 1 View Scheme

1: ethanol 2: aqueous hydrochloric acid View Scheme

1: aqueous hydrochloric acid View Scheme

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