4-羟基-[1,1-联苯]-4-羧酸甲酯合成路线 （共 23 条）
反应条件
potassium carbonate in methanol; thionyl chloride; water; N,N-dimethyl-formamide
参考文献
Showa Shell Sekiyu K.K.
Patent: US5167861 A1, 1992 ;
反应条件
1: With potassium carbonate in butanone Heating; 2: With potassium hydroxide in ethanol; water 0.5 h; Heating; 3: With hydrogenchloride in water 3 h; Heating;
参考文献
Tokushige; Mihara; Koide
Molecular Crystals and Liquid Crystals, 2004 , vol. 414, p. 27 - 38
反应条件
1.1: caesium carbonate; potassium carbonate / acetone / 0.08 h / |Inert atmosphere 1.2: 72 h / |Inert atmosphere; |Reflux 2.1: lithium hydroxide hydrate / water; tetrahydrofuran / 16 h / |Reflux 2.2: pH 2 View Scheme
参考文献
Tsai, Ethan; Richardson, Jacqueline M.; Korblova, Eva; Nakata, Michi; Chen, Dong; Shen, Yongqiang; Shao, Renfan; Clark, Noel A.; Walba, David M.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 20 p. 5254 - 5257
Angew. Chem., 2013 , vol. 125, # 20 p. 5362 - 5365,4
反应条件
potassium carbonate in acetonitrile 6 h; Heating;
参考文献
Colabufo, Nicola Antonio; Berardi, Francesco; Cantore, Mariangela; Perrone, Maria Grazia; Contino, Marialessandra; Inglese, Carmela; Niso, Mauro; Perrone, Roberto; Azzariti, Amalia; Simone, Grazia Maria; Paradiso, Angelo
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 3732 - 3743
反应条件
1: K2CO3 / dimethylformamide 2: NaOH / ethanol View Scheme
参考文献
Debono, Manuel; Turner, William W.; LaGrandeur, Lisa; Burkhadt, Fred J.; Nissen , Jeffrey S.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3271 - 3281
反应条件
1: With potassium carbonate in butanone 6 h; Heating; 2: With potassium hydroxide in ethanol; water 0.5 h; Heating; 3: With hydrogenchloride in water 3 h; Heating;
参考文献
Tokushige; Mihara; Koide
Molecular Crystals and Liquid Crystals, 2004 , vol. 414, p. 27 - 38
反应条件
sulfuric acid in toluene
12 h; Reflux;
参考文献
National Chiao Tung University; CHUNGHWA PICTURE TUBES, LTD.
Patent: US2012/289731 A1, 2012 ;
Location in patent: Page/Page column 2-3 ;
反应条件
sulfuric acid in methanol
参考文献
Abbott Laboratories
Patent: US6316475 B1, 2001 ;
反应条件
in methanol; hexane; benzene
T=20°C; 12 h;
参考文献
Green, Nora S.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of the American Chemical Society, 2003 , vol. 125, # 44 p. 13404 - 13414
反应条件
sodium carbonate; bis(dibenzylideneacetone)-palladium(0); C78H99N6P(6+)*6Br(1-) in methanol; water
T=65°C; Suzuki-Miyaura cross-coupling; 3 h; Inert atmosphere;
参考文献
Snelders, Dennis J. M.; Kreiter, Robert; Firet, Judith J.; Van Koten, Gerard; Gebbink, Robertus J. M. Klein
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 2 p. 262 - 266
