1-(4-氟-苯基)-4-环己酮合成路线 （共 9 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate
P=2585.81 Torr; 1 h;
参考文献
WARNER-LAMBERT COMPANY
Patent: EP1251128 A1, 2002 ;
Location in patent: Page 40 ;
EP 1251128 A1
反应条件
hydrogenchloride in methanol hydrate
参考文献
Bristol-Myers Squibb Co.
Patent: US5352678 A1, 1994 ;
US 5352678 A
反应条件
hydrogenchloride; palladium in 1,4-dioxane; dichloromethane; water
参考文献
Pfizer Inc.
Patent: US5484917 A1, 1996 ;
US 5484917 A
反应条件
1: With hydrogenchloride in water
T=20°C; 2 h;
2: With sodium hydroxide in water
T=0°C;
参考文献
Pfizer Inc
Patent: US6664258 B1, 2003 ;
Location in patent: Page column 21 ;
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 20 °C
2: hydrogenchloride / tetrahydrofuran; water / Reflux
View Scheme
参考文献
Mueller, Steffen; Webber, Matthew J.; List, Benjamin
Journal of the American Chemical Society, 2011 , vol. 133, # 46 p. 18534 - 18537
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux
1.2: 20 °C / |Reflux
2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C
3.1: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 5 h / 30003 Torr
4.1: sulfuric acid / tetrahydrofuran; water / 1.5 h
View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 41 p. 17023 - 17026,4
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux
1.2: 20 °C / |Reflux
2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C
3.1: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 5 h / 30003 Torr
4.1: sulfuric acid / tetrahydrofuran; water / 1.5 h
View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 41 p. 17023 - 17026,4
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux
1.2: 24 h / |Reflux
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / pyridine / 2.5 h / 0 - 80 °C
3.1: palladium 10 on activated carbon; hydrogen / ethyl acetate; methanol / 5 h / 30003 Torr
4.1: tetrahydrofuran; water; sulfuric acid / 1.5 h
View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 49 p. 20208 - 20208
反应条件
(i) CF3CO2H, (ii) H2, Pd-C; Multistep reaction;
参考文献
Lednicer,D. et al.
Journal of Medicinal Chemistry, 1972 , vol. 15, # 12 p. 1239 - 1243
